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2.A.60.1.2
Prostaglandin transporter, Pgt or PGT (SLC21A2) (substrates: eicosanoids including several prostaglandins and thromboxanes). Prostaglandins (PGs) transported include PGE2 PGF and PGH2 (Chi and Schuster, 2010).  Pgt is an important mediator of ovulation, and its inhibitors are potential candidates for nonhormonal contraception (Yerushalmi et al. 2016). PGT is involved in the clearance of PGE2 from the brain during the recovery phase of LPS-induced acute-phase responses (Hosotani et al. 2015).

Accession Number:Q00910
Protein Name:PGT aka Slc21a2
Length:643
Molecular Weight:70569.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Prostaglandin, Eicosanoids, Thromboxanes

Cross database links:

Genevestigator: Q00910
eggNOG: roNOG08472
RefSeq: NP_073158.1   
Entrez Gene ID: 24546   
Pfam: PF07648    PF03137   
KEGG: rno:24546   

Gene Ontology

GO:0016021 C:integral to membrane

References (2)

[1] “Molecular cloning of matrin F/G: a DNA binding protein of the nuclear matrix that contains putative zinc finger motifs.”  Hakes D.J.et.al.   2068100
[2] “Identification and characterization of a prostaglandin transporter.”  Kanai N.et.al.   7754369

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLLLKPGAR QGSGTSSVPD RRCPRSVFSN IKVFVLCHGL LQLCQLLYSA YFKSSLTTIE 
61:	KRFGLSSSSS GLISSLNEIS NATLIIFISY FGSRVNRPRM IGIGGLLLAA GAFVLTLPHF 
121:	LSEPYQYTST TDGNRSSFQT DLCQKHFGAL PPSKCHSTVP DTHKETSSLW GLMVVAQLLA 
181:	GIGTVPIQPF GISYVDDFAE PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD 
241:	TATVNLSPGD PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV TAEETMQTEE 
301:	DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK FLEKQYGATA 
361:	AYANFLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA ATIITISMIL CVPLFFMGCS 
421:	TSAVAEVYPP STSSSIHPQQ PPACRRDCSC PDSFFHPVCG DNGVEYVSPC HAGCSSTNTS 
481:	SEASKEPIYL NCSCVSGGSA SQDRLMPHVL RALLLPSIFL ISFAALIACI SHNPLYMMVL 
541:	RVVNQDEKSF AIGVQFLLMR LLAWLPAPSL YGLLIDSSCV RWNYLCSGRR GACAYYDNDA 
601:	LRNRYLGLQM VYKALGTLLL FFISWRMKKN REYSLQENTS GLI