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2.A.60.1.3
Organic anion transporter, Oat3a (SLC21A7; Oatp1a5; Slco1a5; The mouse ortholog is Q91YY5) (substrates: thyroid hormones (triiodothyronine and thyroxine) cholate, taurocholate hormones and their conjugates, eicosanoids,  other organic anions and cations).  Mediates uptake of ciprofloxacin in mice (Arakawa et al. 2012). Also, microcystin-leucine arginine (MC-LR) enters gonadotropin-releasing hormone (GnRH) neurons and induces decline of serum GnRH levels, resulting in male reproductive toxicity via hypothalamic- pituitary-testis axis (Jin et al. 2019).

Accession Number:O88397
Protein Name:OAT3 aka SLC21A7 aka OATP3
Length:670
Molecular Weight:74577.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Triiodothyronine, Thyroxine, Cholate, taurocholate, Eicosanoids, Organoanions, Organocations, Ciprofloxacin

Cross database links:

Genevestigator: O88397
eggNOG: maNOG12561
RefSeq: NP_110465.1   
Entrez Gene ID: 80900   
Pfam: PF07648    PF03137   
KEGG: rno:80900   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015125 F:bile acid transmembrane transporter activity
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015349 F:thyroid hormone transmembrane transporter a...
GO:0015721 P:bile acid and bile salt transport
GO:0050892 P:intestinal absorption
GO:0031100 P:organ regeneration
GO:0015711 P:organic anion transport

References (2)

[1] “Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2.”  Abe T.et.al.   9712861
[2] “Expression, transport properties, and chromosomal location of organic anion transporter subtype 3.”  Walters H.C.et.al.   11093941

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ FDIPTSIVGF 
61:	INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC FLMSLPHFLM GRYEYETTIS 
121:	PTSNLSSNSF LCMENRSQTL KPTQDPAECI KEMKSLMWIY VLVGNIIRGI GETPIMPLGI 
181:	SYIEDFAKSE NSPLYIGILE TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR 
241:	WVGAWWIGFL ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG 
301:	ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TAEVVLLIGV 
361:	YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL LYFLHFMITC DNFPVAGLTA 
421:	SYEGVHHPLY VENKVLADCN RGCSCSTNSW DPVCGDNGLA YMSACLAGCK KSVGTGTNMV 
481:	FQNCSCIRSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK 
541:	PEEKSLGIGL HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI 
601:	YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE CTDVHGSPQV 
661:	ENDGELKTRL