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2.A.60.1.6
Mouse liver Oatp2 (Slco1a4, Oatp1a4) of 670 aas and 12 TMSs in a 3 + 3 + 3 + 3 + 3 arrangement. Substrates include estrone-3-sulfate, dehydroepiandrosterone sulfate, ouabain, β-lactam antibiotics, BQ-123, digoxin (Km = 5.7 μM), bromosulfophthalein but not taurocholate, rocuronium or deltorphin II. Also transports thyroid hormones. Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011). It catalyzes transport of substrate drugs with neuroprotective properties across the blook-brain barrier (BBB) (Abdullahi et al. 2017).

Accession Number:Q9EP96
Protein Name:OATp2 aka Slc21a5
Length:670
Molecular Weight:73965.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Estrone-3-sulfate, Dehydroepiandrosterone sulfate, Ouabain, Beta-lactam antibiotics, BQ-123, Digoxin, Bromosulfophthalein, Thyroid hormones

Cross database links:

Genevestigator: Q9EP96
HEGENOM: HBG717600
RefSeq: NP_109612.1   
Entrez Gene ID: 28250   
Pfam: PF07648    PF03137   
KEGG: mmu:28250   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005215 F:transporter activity
GO:0006820 P:anion transport

References (1)

[1] “Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2.”  Ogura K.et.al.   11181066

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGKSEKEVAT HGVRCFSKIK AFLLALTCAY VSKSLSGTYM NSMLTQIERQ FGIPTSVVGL 
61:	INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC FLISIPHFLM GRYEYETTIL 
121:	PTSNLSSNSF VCTENRTQTL KPTQDPTECV KEMKSLMWIY VLVGNIIRGM GETPIMPLGI 
181:	SYIEDFAKSE NSPLYIGILE TGMTIGPLIG LLLGSSCANI YVDTGSVNTD DLTITPTDTR 
241:	WVGAWWIGFL VCAGVNILTS IPFFFFPKTL LKEGLQDNGD GTENAKEEKH REKIKEENRG 
301:	ITKDFFLFMK SLSCNPIYMI FILISVIQVN AFINSFTFMP KYLEQQYGKS TAEIVFLMGL 
361:	YMLPPICLGY LIGGLIMKKF KITVKKAAYI GFWLSLTEYL LSFVSYIMTC DNFPVAGLTT 
421:	SYEGVQHPLY VENNVLADCN TKCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGTGTNMV 
481:	FQNCSCIQSS GNASAVLGLC DKGPECANKL QYFLIISIIG CFIFSLGAIP GYMVLLRCMK 
541:	SEEKSLGVGL HTFCMRILGG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYDINSFRRI 
601:	YLGLPAALRG ASFLPALFIL ILMRKFQFPG DIDSSDTDPA EMKLTAKESK CTNVHRSPTM 
661:	QNDGERKTKL