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2.A.60.1.8
Oat4 (SLC21A10). Transports bile salts, eicosanoids, urate, hormones and their conjugates, toxins and other anions.  Functions in urate reabsorption across the renal appical membrane (Prestin et al. 2014).

Accession Number:Q9QZX8
Protein Name:OAT4 aka SLC21A10
Length:652
Molecular Weight:72767.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate bile salts, Eicosanoids, Urate, Hormones, Toxins, anions

Cross database links:

Genevestigator: Q9QZX8
eggNOG: maNOG15010
RefSeq: NP_113838.1   
Entrez Gene ID: 58978   
Pfam: PF07648    PF03137   
KEGG: rno:58978   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0015125 F:bile acid transmembrane transporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0015198 F:oligopeptide transporter activity
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015721 P:bile acid and bile salt transport
GO:0015893 P:drug transport
GO:0006811 P:ion transport
GO:0001889 P:liver development
GO:0006857 P:oligopeptide transport
GO:0046677 P:response to antibiotic
GO:0051384 P:response to glucocorticoid stimulus
GO:0033993 P:response to lipid
GO:0032496 P:response to lipopolysaccharide
GO:0043434 P:response to peptide hormone stimulus

References (5)

[1] “Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1.”  Kakyo M.et.al.   10500057
[2] “Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene.”  Choudhuri S.et.al.   10903899
[3] “Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver.”  Cattori V.et.al.   10838093
[4] “Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3.”  Cattori V.et.al.   11713643
[5] “Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.”  Moser K.et.al.   16396499

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDHTQQSRKA AEAQPSRSKQ TRFCDGFKLF LAALSFSYIC KALGGVVMKS SITQIERRFD 
61:	IPSSISGLID GGFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGSIL TALPHFFMGY 
121:	YKYAKENDIG SLGNSTLTCF INQMTSPTGP SPEIVEKGCE KGLKSHMWIY VLMGNMLRGI 
181:	GETPIVPLGI SYLDDFAKEG HTSMHLGTLH TIAMIGPILG FIMSSVFAKI YVDVGYVDLN 
241:	SVRITPNDAR WVGAWWLSFI VNGLLCITSS IPFFFLPKIP KRSQEERKNS VSLHAPKTDE 
301:	EKKHMTNLTK QEEQDPSNMT GFLRSLRSIL TNEIYVIFLI LTLLQVSGFI GSFTYLFKFI 
361:	EQQFGRTASQ ANFLLGIITI PTMATAMFLG GYIVKKFKLT SVGIAKMNPV DSHIDVPLSY 
421:	CNSDCSCDKN QWEPICGENG VTYISPCLAG CKSFRGDKKP NNTEFYDCSC ISNSGNNSAH 
481:	LGECPRYKCK TNYYFYIILQ VTVSFFTAMG SPSLILILMK SVQPELKSLA MGFHSLIIRA 
541:	LGGILAPIYY GAFIDRTCIK WSVTSCGKRG ACRLYNSRLF GFSYLGLNLA LKTPPLFLYV 
601:	VLIYFTKRKY KRNDNKTLEN GRQFTDEGNP DSVNKNGYYC VPYDEQSNET PL