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2.A.61.1.2
Cryptic C4-dicarboxylate transporter, DcuD (YhcL) (Janausch and Unden 1999).

Accession Number:P45428
Protein Name:Putative cryptic C4-dicarboxylate transporter DcuD
Length:455
Molecular Weight:48831.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate C4-dicarboxylates

Cross database links:

Genevestigator: P45428
EchoBASE: EB2669
EcoGene: EG12818
eggNOG: COG3069
HEGENOM: HOG000274996
DIP: DIP-9412N
Entrez Gene ID: 946575   
Pfam: PF03606   
KEGG: eco:b3227   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015556 F:C4-dicarboxylate transmembrane transporter activity

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “The dcuD (former yhcL) gene product of Escherichia coli as a member of the DcuC family of C4-dicarboxylate carriers: lack of evident expression.”  Janausch I.G.et.al.   10525738
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFGIIISVIV LITMGYLILK NYKPQVVLAA AGIFLMMCGV WLGFGGVLDP TKSSGYLIVD 
61:	IYNEILRMLS NRIAGLGLSI MAVGGYARYM ERIGASRAMV SLLSRPLKLI RSPYIILSAT 
121:	YVIGQIMAQF ITSASGLGML LMVTLFPTLV SLGVSRLSAV AVIATTMSIE WGILETNSIF 
181:	AAQVAGMKIA TYFFHYQLPV ASCVIISVAI SHFFVQRAFD KKDKNINHEQ AEQKALDNVP 
241:	PLYYAILPVM PLILMLGSLF LAHVGLMQSE LHLVVVMLLS LTVTMFVEFF RKHNLRETMD 
301:	DVQAFFDGMG TQFANVVTLV VAGEIFAKGL TTIGTVDAVI RGAEHSGLGG IGVMIIMALV 
361:	IAICAIVMGS GNAPFMSFAS LIPNIAAGLH VPAVVMIMPM HFATTLARAV SPITAVVVVT 
421:	SGIAGVSPFA VVKRTAIPMA VGFVVNMIAT ITLFY