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2.A.62.1.2
NhaD Na+(Li+)/H+ antiporter (Liu et al., 2005).  AaNhaD is from the soda lake alkaliphile, Alkalimonas amylolytica, is crucial for the bacterium's resistance to salt/alkali stresses (Zhong et al. 2012).

Accession Number:Q56EB3
Protein Name:NhaD
Length:483
Molecular Weight:53445.00
Species:Alkalimonas amylolytica [152573]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, Li+, H+

Cross database links:

Pfam: PF03600   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015137 F:citrate transmembrane transporter activity
GO:0015746 P:citrate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Alkalimonas amylolytica gen. nov., sp. nov., and Alkalimonas delamerensis gen. nov., sp. nov., novel alkaliphilic bacteria from soda lakes in China and East Africa.”  Ma Y.et.al.   14986177
[2] “The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment.”  Liu J.et.al.   16267283

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQSLRCVSWL AGLLCLLFST PVFAASAAPL DLTSSLVGFV CIAIFVVAYV LVMGEEKLHM 
61:	RKSKPVLVAA GLIWILIGWV YISRDIPDVT EAAFRHNLLE FAELMLFLLV AMTYINALEE 
121:	RRLFDALRAW MIRKGFSYQN LFWITGFLSF FISPIADNLT TALLMCAVVM KVAEGDKRFI 
181:	NLCCVNIVIA ANAGGAFSPF GDITTLMVWQ AGLVRIDEFL VLFFPALVNY LIPAAVMSFF 
241:	VEKRQPSAVY EDVELKRGAL RILTLFLLTV ATAVLCHSLL HLPPVLGMMM GLGYLQFFGY 
301:	FLRMTLPGSL ARKRAMAERE GDQEKLKRLG GVVPFDVFSR VSRAEWDTLL FFYGIVMCVG 
361:	GLGFLGYLGL MSDLLYEGWN PTSANILLGV ISAVIDNIPV MFAVLAMQPE MSHGHWLLIT 
421:	LTAGVGGSLL SIGSAAGVAL MGQARGYYTF FGHLKWAPVI FIGYIASIAV HLWLNADLFH 
481:	IYD