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2.A.66.1.11
The Enhanced Disease Susceptibility Protein (EDS5), also called the Salicylate Induction Deficient (Sid1) protein; a chloroplast isochorismate exporter that exports isochorismate from the plastid to the cytosol (Rekhter et al. 2019).

Accession Number:Q945F0
Protein Name:EDS5
Length:543
Molecular Weight:59528.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Salicylate

Cross database links:

Genevestigator: Q945F0
HEGENOM: HBG592655
RefSeq: NP_195614.2   
Entrez Gene ID: 830058   
Pfam: PF01554   
KEGG: ath:AT4G39030   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0009536 C:plastid
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006952 P:defense response
GO:0006855 P:drug transmembrane transport
GO:0031348 P:negative regulation of defense response
GO:0009624 P:response to nematode
GO:0009697 P:salicylic acid biosynthetic process

References (2)

[1] “EDS5, an essential component of salicylic acid-dependent signaling for disease resistance in Arabidopsis, is a member of the MATE transporter family.”  Nawrath C.et.al.   11826312
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLIKSQRLTL FSPLLSKTRR IPVNSHQTLV AESVITRRTL GAITATPSFH KNPVVIRRRI 
61:	KLERVTRNCV RIDREIDEEE EEEEKERGDL VKQSIWEQMK EIVKFTGPAM GMWICGPLMS 
121:	LIDTVVIGQG SSIELAALGP GTVLCDHMSY VFMFLSVATS NMVATSLAKQ DKKEAQHQIS 
181:	VLLFIGLVCG LMMLLLTRLF GPWAVTAFTR GKNIEIVPAA NKYIQIRGLA WPFILVGLVA 
241:	QSASLGMKNS WGPLKALAAA TIINGLGDTI LCLFLGQGIA GAAWATTASQ IVSAYMMMDS 
301:	LNKEGYNAYS FAIPSPQELW KISALAAPVF ISIFSKIAFY SFIIYCATSM GTHVLAAHQV 
361:	MAQTYRMCNV WGEPLSQTAQ SFMPEMLYGA NRNLPKARTL LKSLMIIGAT LGLVLGVIGT 
421:	AVPGLFPGVY THDKVIISEM HRLLIPFFMA LSALPMTVSL EGTLLAGRDL KFVSSVMSSS 
481:	FIIGCLTLMF VTRSGYGLLG CWFVLVGFQW GRFGLYLRRL LSPGGILNSD GPSPYTVEKI 
541:	KSI