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2.A.66.1.12
Drug:H+ antiporter (benzalkonium chloride, fluoroquinolone, ethidium bromide, acriflavin, tetraphenylphosphonium chloride efflux pump), PmpM (He et al., 2004)

Accession Number:Q9I3Y3
Protein Name:PmpM norM
Length:477
Molecular Weight:50870.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Benzalkonium chloride, fluoroquinolone, ethidium bromide, acriflavin, Tetraphenylphosphonium chloride, H+

Cross database links:

HEGENOM: HBG479615
RefSeq: NP_250052.1   
Entrez Gene ID: 880959   
Pfam: PF01554   
BioCyc: PAER208964:PA1361-MONOMER   
KEGG: pae:PA1361   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006811 P:ion transport
GO:0006855 P:drug transmembrane transport
GO:0046677 P:response to antibiotic

References (2)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
[2] “An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa.”  He G.-X.et.al.   14679249

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNSPALPLSR GLRIRAELKE LLTLAAPIMI AQLATTAMGF VDAVMAGRAS PHDLAAVALG 
61:	NSIWIPMFLL MTGTLLATTA KVAQRHGAGD QPGTGPLVRQ ALWLALLIGP LSGAVLWWLS 
121:	EPILGLMKVR PELIGPSLLY LKGIALGFPA AALYHVLRCY TNGLGRTRPS MVLGIGGLLL 
181:	NIPINYALIY GHFGMPKMGG PGCGWATGSV MWFMFLGMLF WVNKASIYRA SQLFSRWEWP 
241:	DRATIGPLVA VGLPIGIAVF AESSIFSVIA LLIGGLDENV VAGHQIALNF SALVFMIPYS 
301:	LGMAVTVRVG HNLGAGLPRD ARFAAGVGMA AALGYACVSA SLMLLLREQI AAMYSPDPAV 
361:	IAIAASLIVF SALFQFSDAL QVTAAGALRG YQDTRVTMIM TLFAYWGIGL PVGYSLGLTD 
421:	WFQEPTGPRG LWQGLVVGLT GAAIMLCIRL ARSARRFIRQ HERLQREDAE AASVLGR