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2.A.66.1.15
Electroneutral Multidrug & Toxin Extrusion-1 organic cation:H+ antiporter (MATE-1). Exports tetraethylammonium (TEA) and cimetidine, and probably other organic cations, such as 1-methyl-4-phenylpyridinium, amiloride, imipramine, and quinidine (Ohta et al., 2006).

Accession Number:Q5I0E9
Protein Name:MATE-1
Length:566
Molecular Weight:61440.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate TEA, Cimetidine, 1-methyl-4-phenylpyridinium, Amiloride, Imipramine, Quinidine, H+

Cross database links:

Genevestigator: Q5I0E9
eggNOG: maNOG10762
RefSeq: NP_001009645.1    NP_001014140.1   
Entrez Gene ID: 293502    360539   
Pfam: PF01554   
KEGG: rno:360539   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0005451 F:monovalent cation:hydrogen antiporter activity
GO:0015239 ?:?
GO:0006855 P:drug transmembrane transport
GO:0015695 P:organic cation transport

References (8)

[1] “Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.”  Ohta K.Y.et.al.   16928787
[2] “Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1.”  Terada T.et.al.   16850272
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1.”  Tsuda M.et.al.   17047166
[5] “Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.”  Yokoo S.et.al.   17582384
[6] “Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats.”  Nishihara K.et.al.   17296166
[7] “Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE).”  Asaka J.et.al.   17327464
[8] “Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications.”  Koepsell H.et.al.   17473959

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEVLEEPAPG PGGADAAERR GLRRLLLSGF QEELRALLVL AGPAFLAQLM MFLISFISSV 
61:	FCGHLGKLEL DAVTLAIAVI NVTGISVGHG LSSACDTLIS QTYGSQNLKH VGVILQRGTL 
121:	ILLLCCFPCW ALFINTEQIL LLFRQDPDVS RLTQTYVMVF IPALPAAFLY TLQVKYLLNQ 
181:	GIVLPQVITG IAANLVNALA NYLFLHQLHL GVMGSALANT ISQFALAIFL FLYILWRKLH 
241:	HATWGGWSWE CLQDWASFLQ LAIPSMLMLC IEWWAYEVGS FLSGILGMVE LGAQSITYEL 
301:	AIIVYMIPAG FSVAANVRVG NALGAGNIDQ AKKSSAISLI VTELFAVTFC VLLLGCKDLV 
361:	GYIFTTDWDI VALVAQVVPI YAVSHLFEAL ACTCGGVLRG TGNQKVGAIV NAIGYYVIGL 
421:	PIGISLMFVA KLGVIGLWSG IIICSVCQTS CFLVFIARLN WKLACQQAQV HANLKVNVAL 
481:	NSAVSQEPAH PVGPESHGEI MMTDLEKKDE IQLDQQMNQQ QALPVHPKDS NKLSGKQLAL 
541:	RRGLLFLGVV LVLVGGILVR VYIRTE