TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.66.1.16
Electroneutral organic cation:H+ antiporter MATE2 (Hiasa et al., 2007). 50% identical to MATE1; 2.A.66.1.15.

Accession Number:Q3V050
Protein Name:Slc47a2 aka Mate2
Length:573
Molecular Weight:61789.00
Species:Mus musculus GN=Slc47a2 PE=1 SV=1 [10090]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate organic cations, H+

Cross database links:

Genevestigator: Q3V050
eggNOG: roNOG12275
HEGENOM: HBG746942
RefSeq: NP_001028714.1   
Entrez Gene ID: 380701   
Pfam: PF01554   
KEGG: mmu:380701   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (4)

[1] “Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter.”  Hiasa M.et.al.   17715386
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEPAEDSLGA TIQPPELVRV PRGRSLRILL GLRGALSPDV RREAAALVAL AGPVFLAQLM 
61:	IFLISIVSSI FCGHLGKVEL DAVTLAVSVV NVTGISVGTG LASACDTLMS QSFGGKNLKR 
121:	VGVILQRGIL ILLLCCFPCW AIFLNTERLL LLLRQDPDVA RLAQVYVMIC IPALPAAFLF 
181:	QLQTRYLQSQ GIIMPQVIVG IAANVVNVGM NAFLLYALDL GVVGSAWANT TSQFFLSALL 
241:	FLYVWWKRIH IHTWGGWTRE CFQEWSSYTR LAIPSMFMVC IEWWTFEIGT FLAGLVNVTE 
301:	LGAQAVIYEL ASVAYMVPFG FGVAASVRVG NALGAGNADQ ARCSCTTVLL CAGVCALLVG 
361:	ILLAALKDVV AYIFTNDKDI ISLVSQVMPI FAPFHLFDAL AGTCGGVLRG TGKQKIGAVL 
421:	NTIGYYGFGF PIGVSLMFAA KLGIIGLWAG LIVCVSFQAF SYLIYILRTN WSRVAEQAQV 
481:	RAGLKSTKEL IPTPADLPIL EREVMDGVIL PDIIRPESQT GQLVVEENSQ CAVPTVGEVL 
541:	TGRQLVFYRG MALTVSVAVL IAGIVVRVFN DRG