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2.A.66.1.18
MATE1b (mediates tetraethylammonium (TEA) uptake with properties similar to that of mMATE1; localized in renal brush border membranes (Kobara et al., 2008)).

Accession Number:Q8K0H1
Protein Name:Multidrug and toxin extrusion protein 1
Length:567
Molecular Weight:61642.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs, TEA

Cross database links:

Genevestigator: Q8K0H1
eggNOG: roNOG12275
HEGENOM: HBG746942
RefSeq: NP_080459.2   
Entrez Gene ID: 67473   
Pfam: PF01554   
KEGG: mmu:67473   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (6)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “A human transporter protein that mediates the final excretion step for toxic organic cations.”  Otsuka M.et.al.   16330770
[5] “Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations.”  Hiasa M.et.al.   16641166
[6] “Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter.”  Hiasa M.et.al.   17715386

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERTEESAPG PGGADAASER RGLRCLLLPG FLEELRALLV LAGPAFLAQL MMFLISFISS 
61:	VFCGHLGKLE LDAVTLAIAV INVTGISVGH GLSSACDTLI SQTYGSQNLK HVGVILQRGT 
121:	LILLLCCFPC WALFINTEQI LLLFRQDPDV SRLTQTYVMI FIPALPAAFL YTLQVKYLLN 
181:	QGIVLPQIMT GIAANLVNAL ANYVFLYHLH LGVMGSALAN TISQFALAIF LFLYILWRRL 
241:	HQATWGGWSW ECLQDWASFL RLAIPSMLML CIEWWAYEVG SFLSGILGMV ELGAQSITYE 
301:	LAIIVYMIPS GFSVAANVRV GNALGAGNID QAKKSSAISL IVTELFAVTF CVLLLGCKDL 
361:	VGYIFTTDRD IVALVAQVIP IYAVSHLFEG LACTCGGILR GTGNQKVGAI VNAIGYYVIG 
421:	LPIGIALMFA AKLGVIGLWS GIIICTTCQT TCFLAFIARL NWKRACQQAQ VHANLKVNVA 
481:	LNSAVSHEPA HPVCPESHGE IMMTDLEKKD ETQLDQPMNQ QQALPIRPKD SNKLSGKQLA 
541:	LRRGLLLLGV VLVLVGGILV RVYIRIE