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2.A.66.1.19
JAT1 (transports nicotine and anabasine, and other alkaloids, such as hyoscyamine and berberine, but not flavonoids) (Morita et al., 2009).

Accession Number:B7ZGM0
Protein Name:Putative MATE transporter
Length:470
Molecular Weight:51596.00
Species:Nicotiana tabacum (Common tobacco) [4097]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type II membrane protein2
Substrate Nicotine, Anabasine, Hycoscyamine, Bererine

Cross database links:

Pfam: PF01554   

Gene Ontology

GO:0016020 C:membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVEELPQSLK EKKWQINWDA VSQELKKTSR FMAPMVAVTV FQYLLQVVSV MMVGHLGELA 
61:	LSSVAIATSL TNVTGFSLLT GLVGGMETLC GQAYGAQQYH KLSTYTYTAI ISLFLVCIPI 
121:	CVLWCFMDKL LILTGQDHSI SVEARKYSLW VIPAIFGGAI SKPLSRYSQA QSLILPMLLS 
181:	SFAVLCFHLP ISWALIFKLE LGNIGAAIAF SISSWLYVLF LASYVKLSSS CEKTRAPFSM 
241:	EAFLCIRQFF RLAVPSAVMV CLKWWSFEVL ALVSGLLPNP KLETSVMSIC ITISQLHFSI 
301:	PYGFGAAAST RVSNELGAGN PQKARMAVQV VMFLTVVETL VFNTSLFGSR HVLGKAFSNE 
361:	KQVVDYIAAM TPFLCLSIVT DSLQIVITGI ARGSGWQHIG AYINLVVFYV IAIPLAVVLG 
421:	FVLHLKAKGL WIGIVVGCAI QSIVLSIVTG FTDWEKQAKK ARERVHEGRS