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2.A.66.1.20
Multidrug and Toxin Extrusion Protein 2, MATE-2 (catalyzes drug:H+ antiport; broad specificity, low affinity (50-3000 μM) for organic cationic and anionic compounds (Tanihara et al., 2007)).

Accession Number:Q86VL8
Protein Name:Multidrug and toxin extrusion protein 2
Length:602
Molecular Weight:65085.00
Species:homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs, H+

Cross database links:

Genevestigator: Q86VL8 Q86VL8 Q86VL8 Q86VL8
eggNOG: prNOG17681 prNOG17681 prNOG17681 COG0534
HEGENOM: HBG746942 HBG746942 HBG746942 HOG000060313
RefSeq: NP_001093116.1    NP_690872.2   
Entrez Gene ID: 146802   
Pfam: PF01554   
OMIM: 609833  gene
KEGG: hsa:146802    hsa:146802    hsa:146802    hsa:146802   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport
GO:0055085 P:transmembrane transport

References (24)

[1] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.”  Masuda S.et.al.   16807400
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.”  Omote H.et.al.   16996621
[6] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.”  Tanihara Y.et.al.   17509534
[7] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.”  Masuda S.et.al.   16807400
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.”  Omote H.et.al.   16996621
[12] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.”  Tanihara Y.et.al.   17509534
[13] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.”  Masuda S.et.al.   16807400
[14] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[15] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[16] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[17] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.”  Omote H.et.al.   16996621
[18] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.”  Tanihara Y.et.al.   17509534
[19] “Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.”  Masuda S.et.al.   16807400
[20] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[21] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[22] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[23] “The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.”  Omote H.et.al.   16996621
[24] “Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.”  Tanihara Y.et.al.   17509534

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM IYIVSTVFCG 
61:	HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF GSPNKKHVGV ILQRGALVLL 
121:	LCCLPCWALF LNTQHILLLF RQDPDVSRLT QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL 
181:	KGQEEESPFQ TPGLSILHPS HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV 
241:	LNLGVRGSAY ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML 
301:	MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV RVGMALGAAD 
361:	TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND EDVIALVSQV LPVYSVFHVF 
421:	EAICCVYGGV LRGTGKQAFG AAVNAITYYI IGLPLGILLT FVVRMRIMGL WLGMLACVFL 
481:	ATAAFVAYTA RLDWKLAAEE AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL 
541:	TTYSRSECHV DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT 
601:	RH