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2.A.66.1.21
H+-coupled multidrug efflux pump, AbeM (most like 2.A.66.1.2, NorM of Vibrio cholerae) (Su et al., 2005). Exports norfloxacin, ciprofloxacin, DAPI, acriflavin, Hoechst 33342, daunorubicin, doxorubicin, and ethidium (Su et al., 2005).

Accession Number:Q5FAM9
Protein Name:Multidrug efflux pump AbeM
Length:448
Molecular Weight:48784.00
Species:acinetobacter baumannii [470]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+, norfloxacin, Ciprofloxacin, DAPI, Hoechst 33342, daunorubicin, doxorubicin, ethidium

Cross database links:

Pfam: PF01554   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (1)

[1] “AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters.”  Su X.Z.et.al.   16189122

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNVTSFRSE LKQLFHLMLP ILITQFAQAG FGLIDTIMAG HLSAADLAAI AVGVGLWIPV 
61:	MLLFSGIMIA TTPLVAEAKG ARNTEQIPVI VRQSLWVAVI LGVLAMLILQ LMPFFLHVFG 
121:	VPESLQPKAS LFLHAIGLGM PAVTMYAALR GYSEALGHPR PVTVISLLAL VVLIPLNMIF 
181:	MYGLGPIPAL GSAGCGFATS ILQWLMLITL AGYIYKASAY RNTSIFSRFD KISLTWVKRI 
241:	LQLGLPIGLA VFFEVSIFST GALVLSPLGE VFIAAHQVAI SVTSVLFMIP LSLAIALTIR 
301:	VGTYYGEKNW ASMYQVQKIG LSTAVFFALL TMSFIALGRE QIVSVYTQDI NVVPVAMYLL 
361:	WFAMAYQLMD ALQVSAAGCL RGMQDTQAPM WITLMAYWVI AFPIGLYLAR YTDWGVAGVW 
421:	LGLIIGLSIA CVLLLSRLYL NTKRLSQT