TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.66.1.22
Quinolone:H+ antiporter, EmmdR. Substates include benzalkonium chloride, norfloxacin, ciprofloxacin, levofloxacin, ethidium bromide, acriflavine, rhodamine 6G and trimethoprim.

Accession Number:D5CJ69
Protein Name:MATE efflux family protein
Length:462
Molecular Weight:50233.00
Species:Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56) [716541]
Number of TMSs:11
Substrate Quinolone, H+, Benzalkonium chloride, norfloxacin, Ciprofloxacin, Levofloxacin, ethidium bromide, acriflavine, Rhodamine 6G, Trimethoprim

Cross database links:

Entrez Gene ID: 9127720   
Pfam: PF01554   
KEGG: enc:ECL_03329   

Gene Ontology

GO:0016020 C:membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity

References (1)

[1] “Complete genome sequence of Enterobacter cloacae subsp. cloacae type strain ATCC 13047.”  Ren Y.et.al.   20207761

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRTPWYAKRK SYRVLFWREI TPLAVPIFLE NTCVLLMGVL STFLVSWLGK EAMAGVGLAD 
61:	SFNMVVMSFF AAIDLGTTVV VAFSLGKLDP KRAREAARQS LMIMTLFSII LAAVIHYFGK 
121:	EIIDFVAGEA TNEVKDLALT YLEMTVLSYP AAAIALIGSG ALRGAGNTKI PLLINGGMNI 
181:	LNIMISSVLI YGVFSWEGMG FVGAGLGLTI SRYIGAAAIL GVLMAGITPS LRLTLKSYFR 
241:	PFNFAIIWEV MGIGIPASIE SVLFNAGKLL TQMFVAGMGT DVIAGNFIAF SIASLINLPG 
301:	NALGSASTII TGKRLGKGQI GQAERQLRHV FWLSTIGLTI IAWGSAPFAG LMASFYTHED 
361:	DVKEVVKILI WLNAAFMPIW AASWVLPAGL KGARDARFAM WVSMLGMWGC RVVAGYTLGV 
421:	MLGMGVVGVW LGMFLDWAVR GALFYWRMVS GRWLWKYPRH NA