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2.A.66.1.24
FRD3 efflux pump for citrate; involved in iron homeostasis. Localized to the pericycle and vascular cylinder of roots; loads citrate into xylem tissues facilitating iron transport from the roots to the shoots; null mutants are sterile (Green and Rogers 2004; Roschzttardtz et al., 2011; Green and Rogers 2004; Roschzttardtz et al., 2011; Durrett et al., 2007).

Accession Number:Q9SFB0
Protein Name:MATE efflux family protein FRD3
Length:526
Molecular Weight:55946.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Citrate

Cross database links:

Genevestigator: Q9SFB0
eggNOG: COG0534
HEGENOM: HOG000253153
Entrez Gene ID: 819995   
Pfam: PF01554   
KEGG: ath:AT3G08040   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015137 F:citrate transmembrane transporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0005216 F:ion channel activity
GO:0006879 P:cellular iron ion homeostasis
GO:0071369 P:cellular response to ethylene stimulus
GO:0071281 P:cellular response to iron ion
GO:0071732 P:cellular response to nitric oxide

References (7)

[1] “FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis.”  Rogers E.E.et.al.   12172022
[2] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.”  Salanoubat M.et.al.   11130713
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Functional cloning and characterization of a plant efflux carrier for multidrug and heavy metal detoxification.”  Li L.et.al.   11739388
[5] “FRD3 controls iron localization in Arabidopsis.”  Green L.S.et.al.   15310833
[6] “The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation.”  Durrett T.P.et.al.   17351051
[7] “Aluminum-activated citrate and malate transporters from the MATE and ALMT families function independently to confer Arabidopsis aluminum tolerance.”  Liu J.et.al.   18826429

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTETGDDLAT VKKPIPFLVI FKDLRHVFSR DTTGREILGI AFPAALALAA DPIASLIDTA 
61:	FVGRLGAVQL AAVGVSIAIF NQASRITIFP LVSLTTSFVA EEDTMEKMKE EANKANLVHA 
121:	ETILVQDSLE KGISSPTSND TNQPQQPPAP DTKSNSGNKS NKKEKRTIRT ASTAMILGLI 
181:	LGLVQAIFLI FSSKLLLGVM GVKPNSPMLS PAHKYLSIRA LGAPALLLSL AMQGIFRGFK 
241:	DTKTPLFATV VADVINIVLD PIFIFVLRLG IIGAAIAHVI SQYFMTLILF VFLAKKVNLI 
301:	PPNFGDLQFG RFLKNGLLLL ARTIAVTFCQ TLAAAMAARL GTTPMAAFQI CLQVWLTSSL 
361:	LNDGLAVAGQ AILACSFAEK DYNKVTAVAS RVLQMGFVLG LGLSVFVGLG LYFGAGVFSK 
421:	DPAVIHLMAI GIPFIAATQP INSLAFVLDG VNFGASDFAY TAYSMVGVAA ISIAAVIYMA 
481:	KTNGFIGIWI ALTIYMALRA ITGIARMATG TGPWRFLRGR SSSSSS