TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.66.1.28
Probable multidrug resistance protein NorM (Multidrug-efflux transporter)

Accession Number:Q9WZS2
Protein Name:Probable multidrug resistance protein NorM
Length:464
Molecular Weight:51054.00
Species:Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [243274]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: COG0534
Entrez Gene ID: 898483   
Pfam: PF01554   
KEGG: tma:TM0815   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006811 P:ion transport

References (1)

[1] “Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.”  Nelson K.E.et.al.   10360571

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRYSLFKNYL PKEEVPEIRK ELIKLALPAM GENVLQMLFG MADTAFLGHY SWKAMSGVGL 
61:	SNQVFWVVQV VLIAASMGAT VTIANAIGAG NRKAVRSLAW NSVFLAIFTG VILTALTPLS 
121:	DVLINIFPNL EGEIESSAKE YLKVILSGSM GFSIMAVFSA MLRGAGDTRT PMIVTGLTNF 
181:	LNIFLDYAMI FGKFGFPEMG VRGAAVATIL SRFVGAGILT YVIFKREEFQ LRKGLVPPKW 
241:	SSQKEILRVG FPTAIENFVF STGVLMFANI LLIAGAEAYA GHRIGINVES LSFMPAFGIS 
301:	VAITTLVGRY NGMGNKEHVL GVIRQGWILS LLFQVTVGII IFLFPEPLIR IFTSDPQIIE 
361:	ISKLPVKIIG LFQFFLAIDS TMNGALRGTG NTLPPMIITF ISIWTARLPV AFVMVKYFQL 
421:	GLLGAWIGMI ADIIFRSTLK LLFFLSGKWE KRAVLTRERV KELG