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2.A.66.1.32
Multidrug:proton antiporter of the DinF subfamily.  The structure has been solved to 3.2 Å resolution with and without the substrate, Rhodamine 6 G.  The 12 TMSs show asymmetry with a membrane-embedded substrate-binding chamber.  Direct competition between the H+ and the substrate during transport was suggested (Lu et al. 2013).  However, the opposite was suggested for a sodium antiporter (see TC# 2.A.66.1.10).

Accession Number:Q9KAX3
Protein Name:BH2163 protein
Length:464
Molecular Weight:50634.00
Species:Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [272558]
Number of TMSs:12
Substrate drugs, H+

Cross database links:

Structure:
4LZ6   4LZ9   5C6N   5C6O     

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEQKQQSERL GTEAIPKLLR SLSIPAMIGM FVMALYNVVD TIFISYAVGI EGVAGVTIAF 
61:	PIMMIMMSMA GALGIGGASV ISRRLGERRG EEANQVFGNI LTVILVLSVI GFISAFTLLG 
121:	PALQLFGATS VTQGYATDYL FPILLGSIFF FFAFAANNII RSEGNATFAM VTMIVPAVLN 
181:	ILLDVLFIFG LNMGVLGASI ATVIAQASVT GLVLRYFLTG KSTLSLHWSD LRMKGSVIKE 
241:	VCLVGLPAFV QQSSASLMMI AINSMLLRFG SDFYVGVFGL VQRIMMFVMM PMMGIMQAMQ 
301:	PIVGYNYGAK QYSRLRETVM LGFKVATIFS IGIFALLMLF PEALLRVFTA DREVIQAGVS 
361:	AMHILFCVTF LIGAQIVAGG LYQSLGKPKQ ALILSLSRQI IFLIPLVLIL PHIFGLSGVW 
421:	WAFPIADVLS FILTVVLLYR DRNVFFLKTK EERELDLVKT ASST