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2.A.66.1.6
Drug (norfloxacin, ciprofoxacin, ethidium, tetramethylammonium, pyrrolidinone, polyvinylpyrrolidone) resistance pump, Alf5 or DTOXIFICATION 19, DTX19.  Note:  A. thaliana has 56 MATE transporters (Takanashi et al. 2013).

Accession Number:Q9LUH2
Protein Name:Alf5 aka AT3G23550 aka MDB19.4
Length:477
Molecular Weight:51852.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate norfloxacin, Ciprofloxacin, ethidium, Tetramethylammonium, Pyrrolidinone, Polyvinylpyrrolidone

Cross database links:

Genevestigator: Q9LUH2
eggNOG: KOG1347
HEGENOM: HBG746942
RefSeq: NP_566730.1   
Entrez Gene ID: 821935   
Pfam: PF01554   
KEGG: ath:AT3G23560   

Gene Ontology

GO:0016020 C:membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (1)

[1] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.”  Salanoubat M.et.al.   11130713

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MADPATSSPL LDDHVGGEDE RGRRSRSSTL VQKVIDVEEA KAQMIYSLPM ILTNVFYYCI 
61:	PITSVMFASH LGQLELAGAT LANSWATVSG FAFMVGLSGS LETLCGQGFG AKRYRMLGVH 
121:	LQSSCIVSLV FSILITIFWF FTESIFGLLR QDPSISKQAA LYMKYQAPGL LAYGFLQNIL 
181:	RFCQTQSIIA PLVIFSFVPL VINIATAYVL VYVAGLGFIG APIATSISLW IAFLSLGTYV 
241:	MCSEKFKETW TGFSLESFRY IVINLTLSLP SAAMVCLEYW AFEILVFLAG VMPNPEINTS 
301:	LVAICVNTEA ISYMLTYGLS AAASTRVSNE LGAGNVKGAK KATSVSVKLS LVLALGVVIV 
361:	LLVGHDGWVG LFSDSYVIKE EFASLRFFLA ASITLDSIQG VLSGVARGCG WQRLVTVINL 
421:	ATFYLIGMPI AAFCGFKLKF YAKGLWIGLI CGIFCQSSSL LLMTIFRKWT KLNVATV