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2.A.66.1.7
Cationic drug (4',6'-diamidino-2-phenylindole (DAPI), tetraphenylphosphonium (TPP), acriflavin, ethidium):Na+ antiporter, VmrA

Accession Number:Q93HR7
Protein Name:VmrA
Length:447
Molecular Weight:49314.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate DAPI, TPP, acriflavin, ethidium, Na+

Cross database links:

Pfam: PF01554   

Gene Ontology

GO:0016020 C:membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport

References (1)

[1] “VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus.”  Chen J.et.al.   11751837

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQNSIYKQFW KYTIPTVAAM LVNGLYQVVD GIFIGRYVGA YGLAGINVAW PVIGSILGIG 
61:	MMVGVGTGAL TSIKQGEQDQ QGAKRVLTTG LLFLLALMPI VATILFFLAD DFIRWQGAQG 
121:	RVYELGLQYL QILIVACIFH LALLRFHSCY VTTQPNLATI LMVIGAIINI VLDYVFIAWM 
181:	NWELTGAAIA TALAQMVVTV LGVGYFFSSK AKLRLTFREL KVQLDAIPKI VLIGTSSFFM 
241:	YAYGSTMGSS AQRVIRTIRQ PAFDRRYAIL GYIVTVYYLV AEGIANGMQP LVSYNHGARK 
301:	QDNIRKLLQI AMGTSVLGGV VFVVLMNLFP YQLVSVFNDA DQQLIESAVV GIRLHMFALF 
361:	LDGFLVVAGA YYQSVNKGSK AMFVTVGNML IQLPFLFIMP KLLGVTGIWI AFPLSNIALS 
421:	LVVMSMLWRD IKKLMVDRPV EPSIQAS