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2.A.66.1.9
Drug (norfloxacin, polymyxin B) resistance efflux pump, NorM

Accession Number:Q9F5N7
Protein Name:NorM
Length:462
Molecular Weight:47860.00
Species:Burkholderia vietnamiensis [60552]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate norfloxacin, Polymyxin B

Cross database links:

Pfam: PF01554   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport
GO:0046677 P:response to antibiotic
GO:0006814 P:sodium ion transport

References (1)

[1] “Cloning and characterization of the Burkholderia vietnamiensis norM gene encoding a multi-drug efflux protein.”  Fehlner-Gardiner C.C.et.al.   12399047

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSHSGLTRTA AAPPSLSRHA VDTARLAAPL AIAQLSQMAM SVTDTVLLGS LGPDSLAAGG 
61:	LGANFFFVIV TVLQGVLSSV SVSVAHARGA QAEHRVPHIY WTGFVLSVLL AIPAVVALSL 
121:	SEPLLLMFHE PPTLAQHVGE YTGILRFAAL GSLIGVGLMR AFLPAIGAAR RLLWVSIGGI 
181:	GVNAVLNYGL IHGAYGLPRL GFLGSAVATT ITIWLTAFAL IWLLHGRARF RHFVSAARPK 
241:	LPMMGELIGI GWPVAITYGV ESTLFLATGL TVGVLGATAL AAHQIALNVA SVAFMVPLAI 
301:	GQAANVRVGY WIGAGDPVAA RHAGFVALGL GVAFMSLSGL VLILAPHAIV GLYLHLDDPA 
361:	NAATVSLAAS LLGIAAVFQI VDGMQTVGSG ALRGLRDTRI PMLAATFGYW GIGFPTGYWL 
421:	AFHAGLGARG LWWGLAAGLA SVAVLMAWRF HLKTSSLIAA PR