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2.A.66.10.1
Wzx isoprenoid-linked O-antigen precursor glycan translocase.  A 12 TMS topology with N- and C-termini in the cytoplasm has been established, and functionally important residues have been identified (Marolda et al. 2010).  A substrate:proton antiport mechanism has been established (Islam et al. 2013).

Accession Number:F1XYT9
Protein Name:O-antigen flippase Wzx
Length:463
Molecular Weight:51846.00
Species:Escherichia coli O157:H7 str. 1125 [997825]
Number of TMSs:12
Substrate H+, O-antigen precursors

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIMNKIKKIL KFCTLKKYDT SSALGREQER YRIISLSVIS SLISKILSLL SLILTVSLTL 
61:	PYLGQERFGV WMTITSLGAA LTFLDLGIGN ALTNRIAHSF ACGKNLKMSR QISGGLTLLA 
121:	GLSFVITAIC YITSGMIDWQ LVIKGINENV YAELQHSIKV FVIIFGLGIY SNGVQKVYMG 
181:	IQKAYISNIV NAIFILLSII TLVISSKLHA GLPVLIVSTL GIQYISGIYL TINLIIKRLI 
241:	KFTKVNIHAK REAPYLILNG FFFFILQLGT LATWSGDNFI ISITLGVTYV AVFSITQRLF 
301:	QISTVPLTIY NIPLWAAYAD AHARNDTQFI KKTLRTSLKI VGISSFLLAF ILVVFGSEVV 
361:	NIWTEGKIQV PRTFIIAYAL WSVIDAFSNT FASFLNGLNI VKQQMLAVVT LILIAIPAKY 
421:	IIVSHFGLTV MLYCFIFIYI VNYFIWYKCS FKKHIDRQLN IRG