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2.A.66.2.1
Lipopolysaccharide (possibly the O-antigen side chain intermediate) exporter

Accession Number:P37746
Protein Name:RFBX aka RfbX1 aka WZX aka B2037
Length:415
Molecular Weight:45383.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate LPS

Cross database links:

Genevestigator: P37746
EchoBASE: EB1923
EcoGene: EG11980
eggNOG: COG2244
HEGENOM: HBG417561
RefSeq: AP_002637.1    NP_416541.1   
Entrez Gene ID: 946557   
Pfam: PF01943   
BioCyc: EcoCyc:RFBX-MONOMER    ECOL168927:B2037-MONOMER   
KEGG: ecj:JW2022    eco:b2037   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009103 P:lipopolysaccharide biosynthetic process
GO:0006810 P:transport

References (6)

[1] “Genetic analysis of the O-specific lipopolysaccharide biosynthesis region (rfb) of Escherichia coli K-12 W3110: identification of genes that confer group 6 specificity to Shigella flexneri serotypes Y and 4a.”  Yao Z.et.al.   7517390
[2] “Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster.”  Stevenson G.et.al.   7517391
[3] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTNKLSLRR NVIYLAVVQG SNYLLPLLTF PYLVRTLGPE NFGIFGFCQA TMLYMIMFVE 
61:	YGFNLTATQS IAKAADSKDK VTSIFWAVIF SKIVLIVITL IFLTSMTLLV PEYNKHAVII 
121:	WSFVPALVGN LIYPIWLFQG KEKMKWLTLS SILSRLAIIP LTFIFVNTKS DIAIAGFIQS 
181:	SANLVAGIIA LAIVVHEGWI GKVTLSLHNV RRSLADGFHV FISTSAISLY STGIVIILGF 
241:	ISGPTSVGNF NAANTIRNAL QGLLNPITQA IYPRISSTLV LNRVKGVILI KKSLTCLSLI 
301:	GGAFSLILLL GASILVKISI GPGYDNAVIV LMIISPLPFL ISLSNVYGIQ VMLTHNYKKE 
361:	FSKILIAAGL LSLLLIFPLT TLFKEIGAAI TLLATECLVT SLMLMFVRNN KLLVC