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2.A.66.2.7
Lipopolysaccharide (colanic acid) exporter, WzxC

Accession Number:P77377
Protein Name:WzxC aka Wzx aka B2046
Length:492
Molecular Weight:53693.00
Species:Escherichia coli [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate LPS

Cross database links:

Genevestigator: P77377
EchoBASE: EB3346
EcoGene: EG13576
eggNOG: COG2244
HEGENOM: HBG417267
DIP: DIP-11136N
RefSeq: AP_002646.1    NP_416550.1   
Entrez Gene ID: 946581   
Pfam: PF01943   
BioCyc: EcoCyc:G7097-MONOMER    ECOL168927:B2046-MONOMER   
KEGG: ecj:JW2031    eco:b2046   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009103 P:lipopolysaccharide biosynthetic process

References (5)

[1] “Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid.”  Stevenson G.et.al.   8759852
[2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI IALADTLSDF 
61:	GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD LIGDVLNNPD LAPLIKTLSL 
121:	AFVVIPHGQQ FRALMQKELE FNKIGMIETS AVLAGFTCTV VSAHFWPLAM TAILGYLVNS 
181:	AVRTLLFGYF GRKIYRPGLH FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA 
241:	GVAGGYNLAY NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA 
301:	LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK ARVDISFKFN 
361:	VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF VMIKPVLGSS YRQYILSLWL 
421:	PFYLSLPTLV VSYALGIVLK GQLALGMLLA VQIATGVLAF VVMIVLSRHP LVVEVKRQFC 
481:	RSEKMKMLLR AG