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2.A.66.3.2
Endoplasmic reticular RFT1 homologue

Accession Number:Q96AA3
Protein Name:Protein RFT1 homolog
Length:541
Molecular Weight:60335.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate phospholipids

Cross database links:

Genevestigator: Q96AA3
eggNOG: prNOG06304
HEGENOM: HBG314822
RefSeq: NP_443091.1   
Entrez Gene ID: 91869   
Pfam: PF04506   
OMIM: 611908  gene
612015  phenotype
KEGG: hsa:91869   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005319 F:lipid transporter activity
GO:0008643 P:carbohydrate transport
GO:0006869 P:lipid transport

References (4)

[1] “Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate.”  Oriol R.et.al.   12200473
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Human RFT1 deficiency leads to a disorder of N-linked glycosylation.”  Haeuptle M.A.et.al.   18313027
[4] “RFT1 deficiency in three novel CDG patients.”  Vleugels W.et.al.   19701946

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGSQEVLGHA ARLASSGLLL QVLFRLITFV LNAFILRFLS KEIVGVVNVR LTLLYSTTLF 
61:	LAREAFRRAC LSGGTQRDWS QTLNLLWLTV PLGVFWSLFL GWIWLQLLEV PDPNVVPHYA 
121:	TGVVLFGLSA VVELLGEPFW VLAQAHMFVK LKVIAESLSV ILKSVLTAFL VLWLPHWGLY 
181:	IFSLAQLFYT TVLVLCYVIY FTKLLGSPES TKLQTLPVSR ITDLLPNITR NGAFINWKEA 
241:	KLTWSFFKQS FLKQILTEGE RYVMTFLNVL NFGDQGVYDI VNNLGSLVAR LIFQPIEESF 
301:	YIFFAKVLER GKDATLQKQE DVAVAAAVLE SLLKLALLAG LTITVFGFAY SQLALDIYGG 
361:	TMLSSGSGPV LLRSYCLYVL LLAINGVTEC FTFAAMSKEE VDRYNFVMLA LSSSFLVLSY 
421:	LLTRWCGSVG FILANCFNMG IRITQSLCFI HRYYRRSPHR PLAGLHLSPV LLGTFALSGG 
481:	VTAVSEVFLC CEQGWPARLA HIAVGAFCLG ATLGTAFLTE TKLIHFLRTQ LGVPRRTDKM 
541:	T