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2.A.66.4.8
MurJ (MviV) of 475 aas and 14 TMSs. Kuk et al. 2016 presented a crystal structure of MurJ from Thermosipho africanus in an inward-facing conformation at 2.0-A resolution. A hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Their results suggest that alternating access is important for MurJ function, which may be applicable to other MOP superfamily transporters (Kuk et al. 2016).

Accession Number:B7IE18
Protein Name:Putative lipid II flippase MurJ
Length:475
Molecular Weight:54091.00
Species:Thermosipho africanus (strain TCF52B) [484019]
Number of TMSs:14
Substrate polyisoprenoid-linked disaccharide-peptapeptide

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FASTA formatted sequence
1:	MSILFSSILF SIATFFSRIL GLFRDVLFAK YFGVSYELDA YFIAIMFPFF LRKVFGEGAM 
61:	SSAFVPLYSE KSGEEKDKFL SSVINGFSLI ILALVILSYF FPELIINLFG AGSSHETKIL 
121:	AKKLLLITSP SIYFIFLWAI SYSILNTNNK FFWPALTPSI SNITIIIGTF LSTKYGIISP 
181:	TIGFLIGSIL MFFSIIKSII KHKYYFTIKH FPHFLKLFFP TFMTMVVSQI NTVVDMNVVS 
241:	FYDKGSISYL QYASRFYLLP YGLFAVSVST VVLSKISNDR KNFNYHLNDA LKTTLFFTIP 
301:	SMVGLIFLST PIIRFFYEHG AFTSKDTLIT SKILIAYTLG LPFYGIYSTI SRSYHAIKNT 
361:	KTPFIAATIV SLSNIILDII FGLKYGPIGV ALATSIAGII GVLYLLFSVK TFPIKDFLKI 
421:	SLNSLIMLFV IYLTDFTDNE FWFLIQILIG ILVYLIFSSI FYRDLIRRFL YARKK