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2.A.67.1.3
The YJL212c gene protein (oligopeptide transporter, Opt1p; transports the mammalian pentapeptide, enkephalin, and the tripeptide, glutathione)

Accession Number:P40897
Protein Name:YJV2 aka Opt1p aka YJL212c aka J0236 aka HRD799
Length:799
Molecular Weight:91616.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Oligopeptides, Enkephalin, Glutathione

Cross database links:

Genevestigator: P40897
eggNOG: fuNOG07375
HEGENOM: HBG590918
DIP: DIP-5691N
RefSeq: NP_012323.1   
Entrez Gene ID: 853218   
Pfam: PF03169   
KEGG: sce:YJL212C   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005427 F:proton-dependent oligopeptide secondary act...
GO:0006857 P:oligopeptide transport
GO:0015031 P:protein transport
GO:0006790 P:sulfur metabolic process
GO:0055085 P:transmembrane transport

References (7)

[1] “Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X.”  Vandenbol M.et.al.   7725802
[2] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.”  Galibert F.et.al.   8641269
[3] “Enkephalins are transported by a novel eukaryotic peptide uptake system.”  Hauser M.et.al.   10652283
[4] “Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae.”  Bourbouloux A.et.al.   10788431
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSTIYRESDS LESEPSPTPT TIPIQINMEE EKKDAFVKNI DEDVNNLTAT TDEEDRDPES 
61:	QKFDRHSIQE EGLVWKGDPT YLPNSPYPEV RSAVSIEDDP TIRLNHWRTW FLTTVFVVVF 
121:	AGVNQFFSLR YPSLEINFLV AQVVCYPIGR ILALLPDWKC SKVPFFDLNP GPFTKKEHAV 
181:	VTIAVALTSS TAYAMYILNA QGSFYNMKLN VGYQFLLVWT SQMIGYGAAG LTRRWVVNPA 
241:	SSIWPQTLIS VSLFDSLHSR KVEKTVANGW TMPRYRFFLI VLIGSFIWYW VPGFLFTGLS 
301:	YFNVILWGSK TRHNFIANTI FGTQSGLGAL PITFDYTQVS QAMSGSVFAT PFYVSANTYA 
361:	SVLIFFVIVL PCLYFTNTWY AKYMPVISGS TYDNTQNKYN VTKILNEDYS INLEKYKEYS 
421:	PVFVPFSYLL SYALNFAAVI AVFVHCILYH GKDIVAKFKD RKNGGTDIHM RIYSKNYKDC 
481:	PDWWYLLLQI VMIGLGFVAV CCFDTKFPAW AFVIAILISL VNFIPQGILE AMTNQHVGLN 
541:	IITELICGYM LPLRPMANLL FKLYGFIVMR QGLNLSRDLK LAMYMKVSPR LIFAVQIYAT 
601:	IISGMVNVGV QEWMMHNIDG LCTTDQPNGF TCANGRTVFN ASIIWSLPKY LFSSGRIYNP 
661:	LMWFFLIGLL FPLAVYAVQW KFPKFKFAKH IHTPVFFTGP GNIPPSTPYN YSLFFAMSFC 
721:	LNLIRKRWRA WFNKYNFVMG AGVEAGVAIS VVIIFLCVQY PGGKLSWWGN NVWKRTYDND 
781:	YKKFYTLKKG ETFGYDKWW