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2.A.67.1.5
The glutathione (tripeptide) uptake transporter, Opt1 or Pgt1 (Dworeck et al., 2009).  Transports γ-Glu-Cys-Gly and Glu-Cys-Gly (Thakur et al., 2008).  Mutations in the N-terminus allow functional expression in S. cerevisiae (Thakur and Bachhawat 2013).

Accession Number:O14031
Protein Name:Uncharacterized oligopeptide transporter C29B12.10c
Length:851
Molecular Weight:96302.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Endoplasmic reticulum1 / Multi-pass membrane protein2
Substrate Glutathione, Gamma-Glu-Cys-Gly, Glu-Cys-Gly

Cross database links:

eggNOG: fuNOG07375
HEGENOM: HBG590918
RefSeq: NP_594987.1   
Entrez Gene ID: 2542082   
Pfam: PF03169   
KEGG: spo:SPAC29B12.1   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005887 C:integral to plasma membrane
GO:0034634 F:glutathione transmembrane transporter activity
GO:0033554 P:cellular response to stress
GO:0034775 P:glutathione transmembrane transport
GO:0015031 P:protein transport
GO:0046686 P:response to cadmium ion

References (3)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372
[3] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTARNSASIP TSIRKTSENE VSGDETPAGV GNLSTKTASK TSLTFRQSSS DESTSSYSGN 
61:	HHNINIQHHP NRPFRTNSSS FSPNDYSISE SPSKSKKDGV HVSAVQLDNE TDSEVESEVE 
121:	ELERELEAIE DSVYPEVRAA VNPTDDVNLP VNTWRTWVLT TIFVIVFAAV NQFFSLRYPA 
181:	LSISFIVAQL ILFPLGKLLN LLPNWKIGYG RFSFYLNSSP FNVKEHAAIT IAVSLTSSTA 
241:	YATNILSAQT SFYKQNLSWG YKILIVLTSQ MLGYGFAGLT RRWIVYPAAM IWPQTLVSTV 
301:	LFRTLHGNSG NDIGVLKNNR ISANGWTISR YRFFAYVMIG SFVFYWFPGF IFKGLSYFTV 
361:	LCWIWPKNRV VNQLFGYNSG LGILPLTFDW QQVVYNSNPL ASPWWVICNT FGSVVLIFWI 
421:	VVPILYYKGV WFSNYLPMLS SSTFDHTGVS YNSSRVLNSD YSFNHTKYES YSPLYMPMSY 
481:	SMSTALNFAA VTAIFTHCAL YNGKDIWQRL WKESGKDECI HRKLMRNYKE APQWWYATLF 
541:	IVVFGLTIFT VRYYDTQCPV WALIVALLIF IVNFIPQGVL EGITNQHVGL NIITELIGGY 
601:	ILPGKPLANL MIKLYGFIPM RQGLEFSRDL KLAQYMKIPP RILFFVQLFA TILGGITQVA 
661:	VQEWMNYHIP GICTTSQSNG FTCPNGRSIY NASLIWGAIG PAKMFSKGKP YYPLIFFFLI 
721:	GAVAPFITWG LRKRFPKSWI GKLNAPVLFT GPGNIPPATG INYSSWAIVG FIFNYVIRKR 
781:	AIHWWRKYNY VLAAAMDSGV AVAGVVIFLC VSYPGGKITW WGNTVYTKTY DWKSVPYRSL 
841:	GPNETFGYTN W