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2.A.67.2.2
The probable metal (iron, copper, and zinc) nicotinamide transporter, YSL1 (Waters et al., 2006) (57% identity with YS1).

Accession Number:Q6R3L0
Protein Name:YSL1
Length:673
Molecular Weight:74392.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fe2+-nicotinamide, Cu2+-nicotinamide, Zn2+-nicotinamide

Cross database links:

Genevestigator: Q6R3L0
eggNOG: euNOG04038
HEGENOM: HBG606963
RefSeq: NP_567694.2   
Entrez Gene ID: 828512   
Pfam: PF03169   
KEGG: ath:AT4G24120   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006826 P:iron ion transport
GO:0010039 P:response to iron ion
GO:0055085 P:transmembrane transport

References (6)

[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “Maize yellow stripe1 encodes a membrane protein directly involved in Fe(III) uptake.”  Curie C.et.al.   11201743
[4] “Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis.”  Wintz H.et.al.   13129917
[5] “A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading.”  Le Jean M.et.al.   16297069
[6] “Mutations in Arabidopsis yellow stripe-like1 and yellow stripe-like3 reveal their roles in metal ion homeostasis and loading of metal ions in seeds.”  Waters B.M.et.al.   16815956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEIEQRRIMK REGEEEEDNN QLSLQEEEPD TEEEMSGRTI EPWTKQITVR GVFVSIVIGV 
61:	VFSVIAQKLN LTTGIVPNLN SSAALLAFVF VQTWTKILKK SGFVAKPFTR QENTMIQTSA 
121:	VACYGIAVGG GFASYLLGLN HKTYVLSGVN LEGNSPKSVK EPGLGWMTAY LFVVCFIGLF 
181:	VLIPLRKVMI VDLKLTYPSG LATAVLINGF HTQGDAQAKK QVRGFMKYFS FSFLWGFFQW 
241:	FFSGIEDCGF AQFPTFGLKA WKQTFFFDFS MTFVGAGMIC SHLVNLSLLL GAILSYGLMW 
301:	PLLDKLKGSW FPDNLDEHNM KSIYGYKVFL SVALILGDGL YTFVKILFVT IANVNARLKN 
361:	KPNDLDDVGH KKQRKDLKED ENFLRDKIPM WFAVSGYLTF AAVSTVVVPL IFPQLKWYYV 
421:	IVAYIFAPSL AFCNAYGAGL TDINMAYNYG KIGLFVIAAV TGRENGVVAG LAGCGLIKSV 
481:	VSVSCILMQD FKTAHYTMTS PKAMFASQMI GTVVGCIVTP LSFFLFYKAF DIGNPNGEFK 
541:	APYALIYRNM AILGVQGFSA LPLHCLQMCY GFFGFAVLVN VVRDLTPAKI GRFMPLPTAM 
601:	AVPFLVGAYF AIDMCVGTLI VFVWEKMNRK KAEFMVPAVA SGLICGEGLW TLPAAVLALA 
661:	GVKPPICMKF LAS