TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.67.1.1









Oligopeptide transporter, OPT1
Eukaryota
Fungi
OPT1 of Candida albicans
*2.A.67.1.2









Sexual differentiation process, ISP4 protein (tetra peptide transporter)
Eukaryota
Fungi
ISP4 of Schizosaccharomyces pombe
*2.A.67.1.3









The YJL212c gene protein (oligopeptide transporter, Opt1p; transports the mammalian pentapeptide, enkephalin, and the tripeptide, glutathione)
Eukaryota
Fungi
Opt1p (YJL212c) of Saccharomyces cerevisiae
*2.A.67.1.4









High affinity glutathione uptake porter, Hgt1p or OPT2. TMS 9 plays a role in glutathione recognition (Thakur & Bachhawat et al., 2010; Thakur and Bachhawat 2015). Shows highest affinity for reduced glutathione but also transports oxidized glutathione and glutathione conjugates with lesser affinities (Zulkifli et al. 2016). Residues have been identified that are essential for H+-dependent glutathione uptake (Zulkifli and Bachhawat 2017).

Eukaryota
Fungi
Hgt1p of Saccharomyces cerevisiae (Q06593)
*2.A.67.1.5









The glutathione (tripeptide) uptake transporter, Opt1 or Pgt1 (Dworeck et al., 2009).  Transports γ-Glu-Cys-Gly and Glu-Cys-Gly (Thakur et al., 2008).  Mutations in the N-terminus allow functional expression in S. cerevisiae (Thakur and Bachhawat 2013).

Eukaryota
Fungi
Opt1 of Schizosaccharomyces pombe (O14031)
*2.A.67.1.6









Tetra or penta oligopeptide uptake transporter OPT9 (highly expressed in microspores and bipolar pollen; Bock et al., 2006)

Eukaryota
Viridiplantae
OPT9 of Arabidopsis thaliana (Q9FJD2)
*2.A.67.2.1









'Yellow Stripe1' (YS1) Fe3+-phyto siderophore:H+ symporter. It takes up various metal cations (Fe3+, Zn2+, Cu2+, Ni2+, Mn2+ and Cd2+ when complexed with phytosiderophores, and Ni2+, Fe2+ and Fe3+ when complexed with nicotinamine) (Curie et al., 2001; Schaaf et al., 2004)
Eukaryota
Viridiplantae
YS1 of Zea mays
*2.A.67.2.2









The probable metal (iron, copper, and zinc) nicotinamide transporter, YSL1 (Waters et al., 2006) (57% identity with YS1).
Eukaryota
Viridiplantae
YSL1 of Arabidopsis thaliana (Q6R3L0)
*2.A.67.2.3









The metal (iron and copper)-nicotinamide transporter, YSL2 (mediates lateral movement of metals in the vasculature; DiDonato et al., 2004) (62% identity with YS1).
Eukaryota
Viridiplantae
YSL2 of Arabidopsis thaliana (Q6R3K9)
*2.A.67.2.4









The probable metal (iron, copper, and zinc)-nicotinamide transporter, YSL3; functionally redundant with YSL1 (Waters et al., 2006).
Eukaryota
Viridiplantae
YSL3 of Arabidopsis thaliana (Q2EF88)
*2.A.67.2.5









The rice iron(III)-deoxymugineic acid transporter, YSL18 (specifically expressed in reproductive organs and phloem of lamina joints) (Aoyama et al., 2009).
Eukaryota
Viridiplantae
YSL18 of Oryza sativa (Q941V3)
*2.A.67.2.6









OPT family member
Eukaryota
Dictyosteliida
OPT family homologue of Dictyostelium discoideum (Q54EF1)
*2.A.67.2.7









Putative oligopeptide transporter YGL114W
Eukaryota
Fungi
YGL114W of Saccharomyces cerevisiae
*2.A.67.2.8









The metal-phytosiderophore complex transporter, HvYSL2 (Araki et al. 2011).

Eukaryota
Viridiplantae
HvYSL2 of Hordeum vulgare
*2.A.67.2.9









Yellow stripe-like 7 protein, YSL7; expression gives rise to heavy metal tolerance in Brassica juncea (Wang et al. 2013).

Eukaryota
Viridiplantae
YSL7 in Arabidopsis thaliana
*2.A.67.2.10









Ferric (Fe3+)-phytosiderophore uptake mediator (Yellow stripe like transporter) of 600 aas and 12 TMSs. The outer membrane loop between the sixth and seventh transmembrane regions is essential for substrate specificity. A synthetic peptide corresponding to the loop of HvYS1 forms an alpha-helix in solution, whereas that of the corn orthologue, ZmYS1, is flexible. Harada et al. 2007 proposed that this structural difference determines the narrow substrate specificity of HvYS1 compared to that of ZmYS1 which is of broad specificity.

Eukaryota
Viridiplantae
HvYS1 of Hordeum vulgare (Barley)
*2.A.67.3.1









Early sporulation protein, EspB (temporal control protein)
Bacteria
Proteobacteria
EspB of Myxococcus xanthus
*2.A.67.4.1









Orf HI0561/560
Bacteria
Proteobacteria
Orf of Haemophilus influenzae
*2.A.67.4.2









OPT family member
Archaea
Euryarchaeota
OPT family member from Pyrococcus horikoshii (O58099)
*2.A.67.4.3









OPT family member

Bacteria
Proteobacteria
OPT protein of Caulobacter crescentus (Q9A523)
*2.A.67.5.1









Putative oligopeptide transporter

Bacteria
Proteobacteria
Putative oligopeptide transporter of Myxococcus xanthus