TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.68.1.1









p-Aminobenzoyl-glutamate uptake permease, AbgT (YdaH) (Carter et al., 2007).

Bacteria
Proteobacteria
AbgT (YdaH) of E. coli (P46133)
*2.A.68.1.2









The drug resistance permease, MtrF (Folster and Shafer, 2005).  The 3-d structure is known (Su et al. 2015). MtrF is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer (Su et al. 2015). Each subunit of the transporter contains nine transmembrane helices and two hairpins, posing a plausible pathway for substrate transport. A combination of the crystal structure and biochemical functional assays suggests that MtrF is an antibiotic efflux pump mediating bacterial resistance to sulfonamide antimetabolite drugs (Su et al. 2015). MtrF and YdaH, (TC#2.A.68.1.4) and the dicarboxylate transporter, INDY (TC#2.a.47.5.2) have been shown to have the same 3-d fold (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003).

Bacteria
Proteobacteria
MtrF of Neisseria gonorrhoeae (Q5F721)
*2.A.68.1.3









AbgT homologue of 481 aas

Bacteria
Proteobacteria
AbgT homologue of Brevundimonas subvibrioides (Caulobacter subvibrioides)
*2.A.68.1.4









YdaH transporter of 492 aas with p-aminobenzoyl-glutamate uptake activity.  The crystal structure is known (Bolla et al. 2015). The crystal structure reveals a dimeric molecule with an architecture distinct from other families of transporters. YdaH is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer. Each subunit of the transporter contains nine transmembrane helices and two hairpins that suggest a  pathway for substrate transport. YdaH could act as an antibiotic efflux pump and mediate bacterial resistance to sulfonamide antimetabolite drugs (Bolla et al. 2015).  MtrF (TC#2.A.68.1.2) and YdaH as well as the dicarboxylate transporter, INDY (TC#2.a.47.5.2) have been shown to have similar 3-d folds (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003).

Bacteria
Proteobacteria
YdaH of Alcanivorax borkumensis