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2.A.68.1.4
YdaH transporter of 492 aas with p-aminobenzoyl-glutamate uptake activity.  The crystal structure is known (Bolla et al. 2015). The crystal structure reveals a dimeric molecule with an architecture distinct from other families of transporters. YdaH is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer. Each subunit of the transporter contains nine transmembrane helices and two hairpins that suggest a  pathway for substrate transport. YdaH could act as an antibiotic efflux pump and mediate bacterial resistance to sulfonamide antimetabolite drugs (Bolla et al. 2015).  MtrF (TC#2.A.68.1.2) and YdaH as well as the dicarboxylate transporter, INDY (TC#2.a.47.5.2) have been shown to have similar 3-d folds (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003).

Accession Number:Q0VR69
Protein Name:YdaH protein
Length:492
Molecular Weight:51573.00
Species:Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) [393595]
Number of TMSs:12
Substrate p-Aminobenzoyl-glutamate

Cross database links:

Structure:
4R0C     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTRTHGWLAR LEQLGNRLPH PTLLFVWFCL LLLPLTAVLG ALDVTATHPL TDETITAHSL 
61:	LDADGLRYLF TTLVGNFTGF APLGVVLVAM LGLGVAEQSG LLSVSLASLV RRSSGGALVF 
121:	TVAFAGVLSS LTVDAGYVVL IPLAGLVFQL AGRPPIAGIA TAFAAVSGGF SANLLVGPVD 
181:	ATLAGLSTEA AHIIDPDRTV AATGNYWFII ASTFLVTGLV TLITRTLTEP RLAHANTVAD 
241:	ASVDAPQIHS RAMKWTGLTL AILLAGLALL VLPNDAPLRH PDTGSVLGSP FIHGLVVIVA 
301:	LIAGICGAVY GRVSGQFRNS GAVITAMEVT MASMAGYLVL MFFAAQFVAW FNYSQLGLLL 
361:	AVKGAAWLGA LTVPKVVLLL LFVVLTALIN LMIGSASAKW SILAPVFIPM LMLLGISPEA 
421:	SQAAYRVGDS STNIITPLMP YFVLVLGFAR RYQPETGIGT LIALMLPYSL TLLLGWSVLL 
481:	GVWIGFGWPL GP