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2.A.69.1.1
Auxin efflux carrier, PIN-FORMED 1 (PIN1) (Reinhardt et al., 2003; Carraro et al. 2012). Catalyzes auxin efflux without the participation of any other protein (Petrasek et al., 2006).  PIN1 determines the direction of intercellular auxin flow (Wang et al. 2014). It consists of two TMS bundles, each of 5 TMSs (NodzyƄski et al. 2016), confirming previous bioinformatic predictions (Mansour et al. 2007).

Accession Number:Q9C6B8
Protein Name:Auxin efflux carrier component 1
Length:622
Molecular Weight:67019.00
Species: [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Auxin

Cross database links:

Genevestigator: Q9C6B8
HEGENOM: HBG319549
RefSeq: NP_177500.1   
Entrez Gene ID: 843693   
Pfam: PF03547   
KEGG: ath:AT1G73590   

Gene Ontology

GO:0045177 C:apical part of cell
GO:0009925 C:basal plasma membrane
GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0005215 F:transporter activity
GO:0009734 P:auxin mediated signaling pathway
GO:0009926 P:auxin polar transport
GO:0009630 P:gravitropism
GO:0010338 P:leaf formation
GO:0010358 P:leaf shaping
GO:0009640 P:photomorphogenesis
GO:0048364 P:root development
GO:0055085 P:transmembrane transport
GO:0010051 P:xylem and phloem pattern formation

References (8)

[1] “Regulation of polar auxin transport by AtPIN1 in Arabidopsis vascular tissue.”  Gaelweiler L.et.al.   9856939
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF.”  Steinmann T.et.al.   10514379
[5] “Auxin transport inhibitors block PIN1 cycling and vesicle trafficking.”  Geldner N.et.al.   11574889
[6] “Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis.”  Friml J.et.al.   14614497
[7] “Local, efflux-dependent auxin gradients as a common module for plant organ formation.”  Benkova E.et.al.   14651850
[8] “Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.”  Benschop J.J.et.al.   17317660

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MITAADFYHV MTAMVPLYVA MILAYGSVKW WKIFTPDQCS GINRFVALFA VPLLSFHFIA 
61:	ANNPYAMNLR FLAADSLQKV IVLSLLFLWC KLSRNGSLDW TITLFSLSTL PNTLVMGIPL 
121:	LKGMYGNFSG DLMVQIVVLQ CIIWYTLMLF LFEYRGAKLL ISEQFPDTAG SIVSIHVDSD 
181:	IMSLDGRQPL ETEAEIKEDG KLHVTVRRSN ASRSDIYSRR SQGLSATPRP SNLTNAEIYS 
241:	LQSSRNPTPR GSSFNHTDFY SMMASGGGRN SNFGPGEAVF GSKGPTPRPS NYEEDGGPAK 
301:	PTAAGTAAGA GRFHYQSGGS GGGGGAHYPA PNPGMFSPNT GGGGGTAAKG NAPVVGGKRQ 
361:	DGNGRDLHMF VWSSSASPVS DVFGGGGGNH HADYSTATND HQKDVKISVP QGNSNDNQYV 
421:	EREEFSFGNK DDDSKVLATD GGNNISNKTT QAKVMPPTSV MTRLILIMVW RKLIRNPNSY 
481:	SSLFGITWSL ISFKWNIEMP ALIAKSISIL SDAGLGMAMF SLGLFMALNP RIIACGNRRA 
541:	AFAAAMRFVV GPAVMLVASY AVGLRGVLLH VAIIQAALPQ GIVPFVFAKE YNVHPDILST 
601:	AVIFGMLIAL PITLLYYILL GL