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2.A.69.1.4
Auxin efflux facilitator PIN3: functions in auxin redistribution through the root cap in response to the gravity sensors, ARL2 (Q6XL73) and ARG1 (Q9ZSY2). Both ARG1 and ARL2 are DnaJ homologues and show regions homologous to translocation proteins, NPL1 and Sec63 (3.A.5.8.1 and 3.A.5.9.1, respectively.)

Accession Number:Q9S7Z8
Protein Name:PIN3
Length:640
Molecular Weight:69466.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Auxin

Cross database links:

Genevestigator: Q9S7Z8
HEGENOM: HBG319549
RefSeq: NP_177250.1   
Entrez Gene ID: 843432   
Pfam: PF03547   
KEGG: ath:AT1G70940   

Gene Ontology

GO:0009986 C:cell surface
GO:0016021 C:integral to membrane
GO:0016328 C:lateral plasma membrane
GO:0012506 C:vesicle membrane
GO:0009734 P:auxin mediated signaling pathway
GO:0009926 P:auxin polar transport
GO:0009630 P:gravitropism
GO:0007389 P:pattern specification process
GO:0010082 P:regulation of root meristem growth
GO:0048767 P:root hair elongation
GO:0048766 P:root hair initiation
GO:0055085 P:transmembrane transport

References (5)

[1] “Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis.”  Friml J.et.al.   11845211
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis.”  Friml J.et.al.   14614497
[5] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.”  Reiland S.et.al.   19376835

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MISWHDLYTV LTAVIPLYVA MILAYGSVRW WKIFSPDQCS GINRFVAIFA VPLLSFHFIS 
61:	TNNPYAMNLR FIAADTLQKI IMLSLLVLWA NFTRSGSLEW SITIFSLSTL PNTLVMGIPL 
121:	LIAMYGEYSG SLMVQIVVLQ CIIWYTLLLF LFEFRGAKML IMEQFPETAA SIVSFKVESD 
181:	VVSLDGHDFL ETDAEIGDDG KLHVTVRKSN ASRRSFCGPN MTPRPSNLTG AEIYSLSTTP 
241:	RGSNFNHSDF YNMMGFPGGR LSNFGPADMY SVQSSRGPTP RPSNFEENCA MASSPRFGYY 
301:	PGGGAGSYPA PNPEFSSTTT STANKSVNKN PKDVNTNQQT TLPTGGKSNS HDAKELHMFV 
361:	WSSNGSPVSD RAGLNVFGGA PDNDQGGRSD QGAKEIRMLV PDQSHNGETK AVAHPASGDF 
421:	GGEQQFSFAG KEEEAERPKD AENGLNKLAP NSTAALQSKT GLGGAEASQR KNMPPASVMT 
481:	RLILIMVWRK LIRNPNTYSS LIGLIWALVA FRWHVAMPKI IQQSISILSD AGLGMAMFSL 
541:	GLFMALQPKL IACGNSVATF AMAVRFLTGP AVMAVAAIAI GLRGDLLRVA IVQAALPQGI 
601:	VPFVFAKEYN VHPAILSTGV IFGMLIALPI TLVYYILLGL