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2.A.7.1.1
Small multidrug efflux pump, Smr (QacC, QacD, Ebr).  Substrates: (1) aromatic dyes (e.g., ethidium bromide), (2) quaternary amines (e.g., the disinfectant benzalkonium) and (3) derivatives of tetraphenylphosphonium (TPP) (Fuentes et al. 2005).

Accession Number:P14319
Protein Name:QACC aka Smr aka EBR
Length:107
Molecular Weight:11673.00
Species:Staphylococcus aureus [1280]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Aromatic dyes, Quaternary amines, TPP derivatives

Cross database links:

RefSeq: NP_863640.1    NP_878005.1    YP_534903.1   
Entrez Gene ID: 2598266    2598368    3978602   
Pfam: PF00893   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (6)

[1] “Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus.”  Sasatsu M.et.al.   2602117
[2] “A staphylococcal multidrug resistance gene product is a member of a new protein family.”  Grinius L.et.al.   1615062
[3] “Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus.”  Littlejohn T.G.et.al.   1840534
[4] “High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus.”  Sasatsu M.et.al.   1505735
[5] “Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.”  Tennent J.M.et.al.   2778425
[6] “Molecular characterization of the staphylococcal multidrug resistance export protein QacC.”  Paulsen I.T.et.al.   7751293

External Searches:

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Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPYIYLIIAI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM QHLPLNITYA 
61:	TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL NIFGTSH