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2.A.7.1.11
Small MDR pump, AbeS (53% identical to EmrE of E. coli; TC# 2.A.7.1.3). Exports chloramphenicol, ciprofloxacin, erythromycin, novobiocin, acridine orange, acriflavine, benzalkonium chloride, DAPI, deoxycholate, ethidium bromide, sodium dodecyl sulfate (SDS), tetraphenylphosphonium and others (Srinivasan et al., 2009; Lytvynenko et al. 2015).  Purified AbeS binds tetraphenylphosphonium with nanomolar affinity and exhibits electrogenic transport of 1-methyl-4-phenylpyridinium after reconstitution into liposomes (Lytvynenko et al. 2016).

Accession Number:Q2FD83
Protein Name:QacEdelta1 SMR family efflux pump
Length:109
Molecular Weight:11559.00
Species:Acinetobacter baumannii [470]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Chloramphenicol, erythromycin, Novobiocin, Acridine orange, acriflavine, Benzalkonium chloride, DAPI, Deoxycholate, ethidium bromide, SDS, TPP

Cross database links:

Entrez Gene ID: 6003348   
Pfam: PF00893   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (1)

[1] “Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii.”  Srinivasan V.B.et.al.   19770280

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSYLYLAIAI ACEVIATSAL KASQGFTVPI PSIITVVGYA VAFYLLSLTL KTIPIGIAYA 
61:	IWSGAGIILI SAIGWIFYKQ HLDLAACIGL ALMIAGIVII NVFSKNTHL