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2.A.7.1.2
Small multidrug efflux pump (substrates: isoniazid, tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y) (Rodrigues et al. 2013).

Accession Number:P69926
Protein Name:Multidrug resistance protein mmr aka YU65 aka RV3065 aka MT3150.1 aka MTCY22D7.17C
Length:107
Molecular Weight:11083.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate isoniazid, TPP, erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y

Cross database links:

HEGENOM: HBG740972
RefSeq: NP_337671.1    YP_177922.1   
Entrez Gene ID: 887550    923179   
Pfam: PF00893   
KEGG: mtc:MT3150.1    mtu:Rv3065   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0006810 P:transport

References (3)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.”  De Rossi E.et.al.   9811672
Structure:
2IQ4     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIYLYLLCAI FAEVVATSLL KSTEGFTRLW PTVGCLVGYG IAFALLALSI SHGMQTDVAY 
61:	ALWSAIGTAA IVLVAVLFLG SPISVMKVVG VGLIVVGVVT LNLAGAH