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2.A.7.1.4
Quaternary ammonium compound (cetylpyridinium, cetyldimethyl ethylammonium, hexadecyltrimethyl ammonium) efflux pump

Accession Number:P69937
Protein Name:Quaternary ammonium compound-resistance protein SugE aka B4148 aka SF4306 aka S4571
Length:105
Molecular Weight:10900.00
Species:Escherichia coli [83333]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cetylpyridinium, Cetyldimethyl ethylammonium, Hexadecyltrimethyl ammonium

Cross database links:

Genevestigator: P69937
EchoBASE: EB1573
EcoGene: EG11616
eggNOG: COG2076
HEGENOM: HBG740972
RefSeq: AP_004651.1    NP_418572.4   
Entrez Gene ID: 948671   
Pfam: PF00893   
BioCyc: EcoCyc:SUGE-MONOMER    ECOL168927:B4148-MONOMER   
KEGG: ecj:JW5738    eco:b4148   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (8)

[1] “A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters.”  Greener T.et.al.   8096175
[2] “The entericidin locus of Escherichia coli and its implications for programmed bacterial cell death.”  Bishop R.E.et.al.   9677290
[3] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds.”  Chung Y.J.et.al.   11948170
[7] “High level cell-free expression and specific labeling of integral membrane proteins.”  Klammt C.et.al.   14728684
[8] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSWIILVIAG LLEVVWAVGL KYTHGFSRLT PSVITVTAMI VSMALLAWAM KSLPVGTAYA 
61:	VWTGIGAVGA AITGIVLLGE SANPMRLASL ALIVLGIIGL KLSTH