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2.A.7.1.7
The drug resistance efflux pump, Hsmr (Ninio and Schuldiner, 2003) (exports ethidium, acriflavin tetraphenylphosphonium (TPP) and other cationic drugs).  Inhibited by a peptide with the sequence of TMS4 (Poulsen and Deber 2012). TMS4-TMS4 interactions may constitute the highest affinity locus for dimerization (Poulsen et al. 2009).

Accession Number:B0R6K7
Protein Name:Hsmr
Length:112
Molecular Weight:11293.00
Species:Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) [478009]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ethidium bromide, TPP, Cationic drugs

Cross database links:

HEGENOM: HBG740972
RefSeq: YP_001689722.1   
Entrez Gene ID: 5953143   
Pfam: PF00893   
KEGG: hsl:OE3652F   

Gene Ontology

GO:0016021 C:integral to membrane

References (1)

[1] “Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1.”  Pfeiffer F.et.al.   18313895

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHPYAYLAAA IAAEVAGTTA LKLSEGFSNP APSVVVLVGY VSSFYFLGLV LEELPVGVVY 
61:	GTWAAVGIVA TALVGVVVFE ESVDVAGVVG LALIVAGVVV LNVASDAYTP AH