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2.A.7.10.2
The bifunctional Golgi nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine, SLC35B4 (Ashikov et al., 2005).

Accession Number:Q969S0
Protein Name:UDP-xylose and UDP-N-acetylglucosamine transporter
Length:331
Molecular Weight:37424.00
Species: [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate UDP-xylose, UDP-N-acetylglucosamine

Cross database links:

Genevestigator: Q969S0 Q969S0
eggNOG: prNOG12280 NOG250393
HEGENOM: HBG737529 HOG000234632
RefSeq: NP_116215.1   
Entrez Gene ID: 84912   
Pfam: PF08449   
OMIM: 610923  gene
KEGG: hsa:84912    hsa:84912   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005462 F:UDP-N-acetylglucosamine transmembrane trans...
GO:0005464 F:UDP-xylose transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0015788 P:UDP-N-acetylglucosamine transport
GO:0015790 P:UDP-xylose transport
GO:0005462 F:UDP-N-acetylglucosamine transmembrane transporter activity

References (12)

[1] “The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.”  Ashikov A.et.al.   15911612
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[4] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[5] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.”  Ashikov A.et.al.   15911612
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[10] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[11] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF EADLGRKPPA 
61:	IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSIFK 
121:	YTSIALVSVG IFICTFMSAK QVTSQSSLSE NDGFQAFVWW LLGIGALTFA LLMSARMGIF 
181:	QETLYKRFGK HSKEALFYNH ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW 
241:	FYLLMNIITQ YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT 
301:	LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N