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2.A.7.11.6
UDP-galactose transporter homologue 1 (Multicopy suppressor of leflunomide-sensitivity protein 6)

Accession Number:Q12520
Protein Name:UDP-galactose transporter homologue 1
Length:339
Molecular Weight:38075.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate UDP-galactose

Cross database links:

Genevestigator: Q12520
eggNOG: COG0697
HEGENOM: HOG000091197
DIP: DIP-3958N
Entrez Gene ID: 855832   
Pfam: PF08449   
KEGG: sce:YPL244C   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0015785 P:UDP-galactose transport
GO:0015786 P:UDP-glucose transport

References (6)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[2] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[3] “The Saccharomyces cerevisiae MLF6/YPL244C gene, which encodes a possible yeast homologue of mammalian UDP-galactose transporter, confers resistance to the immunosuppressive drug, leflunomide.”  Fujimura H.et.al.   11391470
[4] “Overexpression of HUT1 gene stimulates in vivo galactosylation by enhancing UDP-galactose transport activity in Saccharomyces cerevisiae.”  Kainuma M.et.al.   11284009
[5] “Hut1 proteins identified in Saccharomyces cerevisiae and Schizosaccharomyces pombe are functional homologues involved in the protein-folding process at the endoplasmic reticulum.”  Nakanishi H.et.al.   11284010
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGSTSSLVI CAIGIYATFL TWALVQEPLA TRTWPNSMGK FQFPNVISLI QASVAMMMGY 
61:	LYLNWKKVEY PPRKMIKDHW KQLMLISFTQ SSSGPLATTS LKHVDYLTYM LAKSCKMIPV 
121:	LLVHLLLYRT PIASQKKVVA LLVSLGVTIF TIGGNDGKKL KRSFNESGND NKLQGFGLLF 
181:	SSLFLDGLTN ATQDKLLKAN KAKEKGKQTL ITGAHLMFTL NLFVILWNIL YFIVIDCKQW 
241:	DNAVSVLTMD PQVWGYLMLY SFCGAMGQCF IFYTLEQFGS LVLIMITVTR KMVSMILSII 
301:	VFGKSVRFQQ WVGMFIVFGG ITWEALNKKK ANIPKAKSA