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2.A.7.12.1
CMP-sialic acid:CMP antiporter. Amino acid residues important for CMP-sialic acid recognition have been identified (Takeshima-Futagami et al., 2012).  Residues essential for activity have been identified (Chan et al. 2010).

Accession Number:Q61420
Protein Name:CMST aka SLC35A1
Length:336
Molecular Weight:36409.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate CMP-sialic acid, CMP

Cross database links:

Genevestigator: Q61420
RefSeq: NP_036025.2   
Entrez Gene ID: 24060   
Pfam: PF04142   
KEGG: mmu:24060   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005338 F:nucleotide-sugar transmembrane transporter ...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0015780 P:nucleotide-sugar transport

References (2)

[1] “Expression cloning of the Golgi CMP-sialic acid transporter.”  Eckhardt M.et.al.   8755516
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPARENVSL FFKLYCLAVM TLVAAAYTVA LRYTRTTAEE LYFSTTAVCI TEVIKLLISV 
61:	GLLAKETGSL GRFKASLSEN VLGSPKELAK LSVPSLVYAV QNNMAFLALS NLDAAVYQVT 
121:	YQLKIPCTAL CTVLMLNRTL SKLQWISVFM LCGGVTLVQW KPAQASKVVV AQNPLLGFGA 
181:	IAIAVLCSGF AGVYFEKVLK SSDTSLWVRN IQMYLSGIVV TLAGTYLSDG AEIQEKGFFY 
241:	GYTYYVWFVI FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVLL FGLQITLSFA 
301:	LGALLVCVSI YLYGLPRQDT TSIQQEATSK ERIIGV