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2.A.7.12.12
Putative Golgi UDP-sugar transporter, SLC35A4. A modulatory role for SLC35A4 in intracellular trafficking of SLC35A2/SLC35A3 complexes has been proposed (Sosicka et al. 2017).

Accession Number:Q96G79
Protein Name:Probable UDP-sugar transporter protein SLC35A4
Length:324
Molecular Weight:34593.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate UDP-sugar

Cross database links:

NOG302854
Genevestigator: Q96G79 Q96G79
HEGENOM: HBG444220 HOG000154235
Entrez Gene ID: 113829   
Pfam: PF04142   
KEGG: hsa:113829    hsa:113829   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005351 F:sugar:hydrogen symporter activity

References (8)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The nucleotide-sugar transporter family: a phylogenetic approach.”  Martinez-Duncker I.et.al.   12770764
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “The nucleotide-sugar transporter family: a phylogenetic approach.”  Martinez-Duncker I.et.al.   12770764

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT 
61:	KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN 
121:	LKIGSTAVLY CLCLRHRLSV RQGLALLLLM AAGACYAAGG LQVPGNTLPS PPPAAAASPM 
181:	PLHITPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG 
241:	SGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL 
301:	QLTAAFFLAT LLIGLAMRLY YGSR