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2.A.7.12.6
Golgi UDP-galactose and UDP-N-acetylgalactosamine:UDP antiporter UGT or SLC35A2 (orthologue of 2.A.7.12.5) (Segawa et al., 2002). Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. Residues essential for activity, and mechanisms of transport by UGT allow greater understanding of the relationship between mutations in this protein and disease (Li and Mukhopadhyay 2019).  

Accession Number:P78381
Protein Name:UGT aka SLC35A2 aka UCALT aka UGTL
Length:396
Molecular Weight:41307.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate UDP galactose

Cross database links:

HOG000231358
Genevestigator: P78381 P78381
eggNOG: prNOG07579 COG0697
RefSeq: NP_001035963.1    NP_005651.1   
Entrez Gene ID: 7355   
Pfam: PF04142   
OMIM: 314375  gene
KEGG: hsa:7355   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005351 F:sugar:hydrogen symporter activity
GO:0005459 F:UDP-galactose transmembrane transporter act...
GO:0006012 P:galactose metabolic process
GO:0015785 P:UDP-galactose transport
GO:0005634 C:nucleus
GO:0005459 F:UDP-galactose transmembrane transporter activity

References (14)

[1] “Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.”  Miura N.et.al.   8889805
[2] “Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.”  Ishida N.et.al.   9010752
[3] “The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus.”  Hara T.et.al.   8128316
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.”  Imami K.et.al.   18187866
[6] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[7] “Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.”  Miura N.et.al.   8889805
[8] “Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.”  Ishida N.et.al.   9010752
[9] “The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus.”  Hara T.et.al.   8128316
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[13] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.”  Imami K.et.al.   18187866
[14] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAVGAGGST AAPGPGAVSA GALEPGTASA AHRRLKYISL AVLVVQNASL ILSIRYARTL 
61:	PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYV DTLKLAVPSL 
121:	IYTLQNNLQY VAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA 
181:	IVQAQQAGGG GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL 
241:	FGTALGLVGL WWAEGTAVAT RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA 
301:	TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS ASASASGPCV 
361:	HQQPPGQPPP PQLSSHRGDL ITEPFLPKLL TKVKGS