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2.A.7.14.4
Purine permease 2 (AtPUP2).  PUP2 transports cytokinins (trans- and cis-zeatin, kinetin, benzyladenine, isopentenyladenine, and to a lesser extent trans-zeatin riboside)

Accession Number:Q94GB1
Protein Name:Purine permease 2
Length:358
Molecular Weight:39461.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate trans-zeatin riboside, isopentenyladenine, benzyladenine, kinetin, zeatin, cytokinins, guanine, Adenine, Purines

Cross database links:

Genevestigator: Q94GB1
eggNOG: NOG239528
HEGENOM: HOG000238172
Entrez Gene ID: 817941   
Pfam: PF00892    PF03151   
KEGG: ath:AT2G33750   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0016020 C:membrane
GO:0005345 F:purine base transmembrane transporter activity

References (3)

[1] “A new family of high-affinity transporters for adenine, cytosine, and purine derivatives in Arabidopsis.”  Gillissen B.et.al.   10662864
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Transport of cytokinins mediated by purine transporters of the PUP family expressed in phloem, hydathodes, and pollen of Arabidopsis.”  Buerkle L.et.al.   12662305

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKMKTVLVII NCIFLAIGNC GGPLMMRLYF QNGGERIWFP SFLQTVGCPL IFFPLLLSFL 
61:	RRRRCLEEQE TTPFFLMKPP LFIAAIVVGL LVGFDNYLYS YGLAYIPVST ASLIISAQLG 
121:	FTALFAFFMV KQKFTPFTIN AIVLLTGGAV VLALNSDSDK LANETHKEYV VGFIMTLGAA 
181:	LLYGFILPLV ELSYKKSGQR ITYTLALEFQ MVLCFAATCV CLVGMLAAGD FKVKHALFIF 
241:	KNRVIAGEAR DFKLGESLYY VVIVFTAIIW QAFFVGAIGL IFCASSLVSG IMVSALLPVT 
301:	VILAVICFQE KFQAGKGVAL ALSLWGSVSY FYGQVKSEEK TKAQDTQLSQ LPVTDYVA