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2.A.7.14.6
Tobacco nicotine uptake permease 1, NUP1, of 353 aas and 10 TMSs. NUP1 transports tobacco alkaloids such as nicotine, but also efficiently takes up pyridoxamine, pyridoxine and anatabine. The naturally occurring (S)-isomer of nicotine was preferentially transported over the (R)-isomer. NUP1, similar to PUP1 of A. thaiana, transported various compounds containing a pyridine ring, but the two transporters had distinct substrate preferences (Kato et al. 2015).

Accession Number:G8A929
Protein Name:Nicotine uptake permease 1
Length:353
Molecular Weight:38831.00
Species:Nicotiana tabacum (Common tobacco) [4097]
Number of TMSs:10
Substrate pyridine-based compounds, Nicotine, anatabine, Pyridoxine, Pyridoxamine, Purines

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FASTA formatted sequence
1:	MEHPGLSTNM RRILLLISCL ILAVGICGGP LMMRLYYVEG GSRIWLSSWL QTGGWPLTLI 
61:	PLAILYYYRR KTEGSNAKFY LMTPRIFIAS FVIGVATGLD DFLYSWGGSK LPVSTSSLLL 
121:	AAQLAFTAVG AFFIVKLKLS PFSINAVVLL TVGAVLLGIR SNGDRPEGVT SKEYIIGFMM 
181:	TLLAAALYGV ILPCIELIYM KAKQAITSTL VLEIQMIMSF AATAFCTVGM IANKDFQAMS 
241:	REAKQFNVGE ARYYTVIVCT AAIWQCFFVG IIGVIYCSSS LMSGVMIAVL LPVTEVLAVI 
301:	FFKENFSGEK GLALFLSLWG FVSYFYGEFR QTKKQKNTSP EAEMTITTHT ESV