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2.A.7.15.1
The Golgi UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter, SQV-7-like protein SQV7L, homologue of Fringe connection protein 1 (involved in Notch signalling by transporting UDP-N-acetylglucosamine) HFRC1, Slc35D1.  Transports UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc), and GDP-mannose (GDP-Man), with apparent Km values of 8, 2, and 0.14 μM, respectively (Suda et al. 2004).

Accession Number:Q76EJ3
Protein Name:SQV7L
Length:337
Molecular Weight:36673.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate UDP-N-acetylglucosamine, UDP-glucose, GDP-mannose

Cross database links:

NOG261892
Genevestigator: Q76EJ3 Q76EJ3
HEGENOM: HBG381255 HOG000038339
RefSeq: NP_008932.2   
Entrez Gene ID: 11046   
Pfam: PF03151   
OMIM: 609182  gene
KEGG: hsa:11046    hsa:11046   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005338 F:nucleotide-sugar transmembrane transporter ...
GO:0008643 P:carbohydrate transport
GO:0005338 F:nucleotide-sugar transmembrane transporter activity

References (10)

[1] “Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.”  Suda T.et.al.   15082721
[2] “Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.”  Ishida N.et.al.   15607426
[3] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway.”  Herman T.et.al.   9927678
[6] “Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.”  Suda T.et.al.   15082721
[7] “Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.”  Ishida N.et.al.   15607426
[8] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway.”  Herman T.et.al.   9927678

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTAGGQAEAE GAGGEPGAAR LPSRVARLLS ALFYGTCSFL IVLVNKALLT TYGFPSPIFL 
61:	GIGQMAATIM ILYVSKLNKI IHFPDFDKKI PVKLFPLPLL YVGNHISGLS STSKLSLPMF 
121:	TVLRKFTIPL TLLLETIILG KQYSLNIILS VFAIILGAFI AAGSDLAFNL EGYIFVFLND 
181:	IFTAANGVYT KQKMDPKELG KYGVLFYNAC FMIIPTLIIS VSTGDLQQAT EFNQWKNVVF 
241:	ILQFLLSCFL GFLLMYSTVL CSYYNSALTT AVVGAIKNVS VAYIGILIGG DYIFSLLNFV 
301:	GLNICMAGGL RYSFLTLSSQ LKPKPVGEEN ICLDLKS