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2.A.7.15.3
Endoplasmic reticulum (ER)/Golgi antiporter for UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose in exchange for UDP, Fringe connection (Frc) Essential for several signalling pathways including heparan sulfate and Fringe-dependent signalling (Selva et al. 2001).  Involved in glycosylation and processing of Notch (Goto et al. 2001).

Accession Number:Q95YI5
Protein Name:UDP-sugar transporter UST74c aka frc
Length:373
Molecular Weight:41182.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate UDP-glucuronic acid, UDP-N-acetylgalactosamine, UDP-xylose

Cross database links:

eggNOG: inNOG05038
DIP: DIP-23605N
RefSeq: NP_001137962.1    NP_524126.1   
Entrez Gene ID: 39943   
Pfam: PF03151   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-017121-MONOMER   
KEGG: dme:Dmel_CG3874   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0005515 F:protein binding
GO:0005459 F:UDP-galactose transmembrane transporter act...
GO:0005460 F:UDP-glucose transmembrane transporter activity
GO:0005461 F:UDP-glucuronic acid transmembrane transport...
GO:0005462 F:UDP-N-acetylglucosamine transmembrane trans...
GO:0005464 F:UDP-xylose transmembrane transporter activity
GO:0001745 P:compound eye morphogenesis
GO:0007447 P:imaginal disc pattern formation
GO:0007476 P:imaginal disc-derived wing morphogenesis
GO:0007367 P:segment polarity determination
GO:0015785 P:UDP-galactose transport
GO:0015786 P:UDP-glucose transport
GO:0015787 P:UDP-glucuronic acid transport
GO:0015788 P:UDP-N-acetylglucosamine transport
GO:0015790 P:UDP-xylose transport

References (5)

[1] “UDP-sugar transporter implicated in glycosylation and processing of Notch.”  Goto S.et.al.   11533661
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[5] “Phosphoproteome analysis of Drosophila melanogaster embryos.”  Zhai B.et.al.   18327897

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSMSRGGNTT LDLQPLLAES DVGNRELEEK MGGSADRSSL LDGSGSKELS HREREDSALF 
61:	VKKIGSALFY GLSSFMITVV NKTVLTSYHF PSFLFLSLGQ LTASIVVLGM GKRLKLVNFP 
121:	PLQRNTFAKI FPLPLIFLGN MMFGLGGTKT LSLPMFAALR RFSILMTMLL ELKILGLRPS 
181:	NAVQVSVYAM IGGALLAASD DLSFNMRGYI YVMITNALTA SNGVYVKKKL DTSEIGKYGL 
241:	MYYNSLFMFL PALALNYVTG NLDQALNFEQ WNDSVFVVQF LLSCVMGFIL SYSTILCTQF 
301:	NSALTTTIVG CLKNICVTYL GMFIGGDYVF SWLNCIGINI SVLASLLYTY VTFRRKRAPD 
361:	KQDHLPSTRG ENV