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2.A.7.15.5
The putative Golgi nucleotide-sugar transporter SLC35D3 (416aas, 10 TMSs) (Chintala et al. 2007).  SLC35D3 regulates tissue-specific autophagy and plays an important role in the increased autophagic activity required for the survival of subsets of dopaminergic neurons (Wei et al. 2016).

Accession Number:Q5M8T2
Protein Name:Solute carrier family 35 member D3
Length:416
Molecular Weight:44183.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate UDP-sugar

Cross database links:

Genevestigator: Q5M8T2 Q5M8T2
eggNOG: prNOG09724 NOG317482
HEGENOM: HBG713710 HOG000090215
Entrez Gene ID: 340146   
Pfam: PF03151   
KEGG: hsa:340146    hsa:340146   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008643 P:carbohydrate transport

References (6)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS TAALSLELLR 
61:	RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS LPMYVVFKRC LPLVTMLIGV 
121:	LVLKNGAPSP GVLAAVLITT CGAALAGAGD LTGDPIGYVT GVLAVLVHAA YLVLIQKASA 
181:	DTEHGPLTAQ YVIAVSATPL LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN 
241:	FTTLHCTYIN SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA 
301:	KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE AAGGPAQESR 
361:	QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR YMKKDYLIEN EELPSP