TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.7.16.2
Golgi GDP-fucose-specific transporter, Gfr or CG9620 (Luhn et al., 2004).  It is required for glycan fucosylation and can also fucosylate NOTCH, a transmembrane cell fate determining receptor (Ishikawa et al. 2010).  Another transporter, the endoplasmic reticular Efr (TC# 2.A.7.10.4), can also fucoslyate NOTCH but not glycans.

Accession Number:Q9VHT4
Protein Name:Probable GDP-fucose transporter aka Gfr
Length:337
Molecular Weight:38107.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate GDP-fucose

Cross database links:

eggNOG: inNOG06488
RefSeq: NP_649782.1   
Entrez Gene ID: 40981   
Pfam: PF03151   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-010520-MONOMER   
KEGG: dme:Dmel_CG9620   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0005798 C:Golgi-associated vesicle
GO:0016021 C:integral to membrane
GO:0005457 F:GDP-fucose transmembrane transporter activity
GO:0015783 P:GDP-fucose transport

References (2)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MYKNLEEHNR LVNKYLKIFF VVSLYWCTSI LTVFVNKHLL SSDTVNLGAP LFMSWFQCVV 
61:	STVICFVASR LSRKYPSVFT FPEGNPLDID TFRKILPLSV LYTLMIGANN LSLSYVTVAF 
121:	YYIGRSLTTV FSVVLTYVIL RQRTSFKCLL CCGAIVVGFW LGVDQESLTE VFSWRGTIFG 
181:	VLSSLALAMF SIQTKKSLGY VNQEVWLLSY YNNLYSTLLF LPLIIINGEL ESIITYPHLW 
241:	ASWFWAAMTL SGLCGFAIGF VTALEIKVTS ALTHNISGTA KACAQTVIAT QYYHDVRSAL 
301:	WWTSNVVVLV ASAAYTRVKQ LEMMRQHQQR STATQKA